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Description
CACNA1S Recombinant Rabbit mAb (S-2448-78)Product Specification Host Rabbit Antigen CACNA1S Synonyms Voltage dependent L type calcium channel subunit alpha 1S; Calcium channel; L type; alpha 1 polypeptide; isoform 3; skeletal muscle; Voltage gated calcium channel subunit alpha Cav1. 1; CACH1; CACN1; CACNL1A3 s Immunogen Synthetic Peptide Location Cell membrane Accession Q13698 Clone Number S 2448 78 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu, Ms, Rt Positive
Product Specification
| Host | Rabbit |
| Antigen | CACNA1S |
| Synonyms | Voltage-dependent L-type calcium channel subunit alpha-1S; Calcium channel; L type; alpha-1 polypeptide; isoform 3; skeletal muscle; Voltage-gated calcium channel subunit alpha Cav1.1; CACH1; CACN1; CACNL1A3 s |
| Immunogen | Synthetic Peptide |
| Location | Cell membrane |
| Accession | Q13698 |
| Clone Number | S-2448-78 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | Human skeletal muscle, mouse skeletal muscle, rat skeletal muscle |
| Predicted Reactivity | Rb |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:4000 | Rt |
| IHC-P | 1:500 | Hu, Ms, Rt |
Background
The CACNA1S protein is a crucial component of the voltage-dependent L-type calcium channel, specifically the alpha-1 subunit, which plays a vital role in excitable cells such as skeletal muscle and cardiac muscle. This protein is encoded by the CACNA1S gene and is responsible for regulating the flow of calcium ions into cells, thereby influencing muscle contraction and other physiological processes. Mutations in the CACNA1S gene can lead to various disorders, including hypokalemic periodic paralysis and malignant hyperthermia susceptibility, highlighting its significance in maintaining normal muscle function and homeostasis.
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