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Description
Atg3 Recombinant Rabbit mAb (S-2168-20)Product Specification Host Rabbit Antigen Atg3 Synonyms Ubiquitin like conjugating enzyme ATG3; Autophagy related protein 3 (APG3 like; hApg3); Protein PC3 96; APG3; APG3L; ATG3 Immunogen Synthetic Peptide Location Cytoplasm Accession Q9NT62 Clone Number S 2168 20 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Rt, Mk Positive Sample HL 60, K562, THP 1, HeLa, A20, mouse kidney, PC 12, COS 7 Predicted Reactivity
Product Specification
| Host | Rabbit |
| Antigen | Atg3 |
| Synonyms | Ubiquitin-like-conjugating enzyme ATG3; Autophagy-related protein 3 (APG3-like; hApg3); Protein PC3-96; APG3; APG3L; ATG3 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm |
| Accession | Q9NT62 |
| Clone Number | S-2168-20 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt, Mk |
| Positive Sample | HL-60, K562, THP-1, HeLa, A20, mouse kidney, PC-12, COS-7 |
| Predicted Reactivity | Bv |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt, Mk |
| IHC-P | 1:200 | Hu |
| ICC | 1:100 | Hu |
Background
Atg3 is an E2-like enzyme essential for autophagosome biogenesis: its C-terminal catalytic cysteine forms a thioester bond with the C-terminal glycine of Atg8-family proteins (LC3/GABARAPs) in an ATP-dependent manner, and subsequently, with the E3-like Atg12–Atg5-Atg16L1 complex, it covalently conjugates Atg8 to phosphatidylethanolamine on the expanding phagophore membrane, thereby driving membrane curvature, expansion, and closure into the double-membrane autophagosome that sequesters cytoplasmic cargo for lysosomal degradation.
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