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Description
MG53 Recombinant Rabbit mAb (S-1659-10)Product Specification Host Rabbit Antigen MG53 Synonyms Tripartite motif containing protein 72; Mitsugumin 53 (Mg53); TRIM72 Immunogen Recombinant Protein Location Cell membrane Accession Q6ZMU5 Clone Number S 1659 10 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu, Ms, Rt Positive Sample HCT 116, mouse heart, rat heart Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage
Product Specification
| Host | Rabbit |
| Antigen | MG53 |
| Synonyms | Tripartite motif-containing protein 72; Mitsugumin-53 (Mg53); TRIM72 |
| Immunogen | Recombinant Protein |
| Location | Cell membrane |
| Accession | Q6ZMU5 |
| Clone Number | S-1659-10 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | HCT 116, mouse heart, rat heart |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:5000 | Hu, Ms, Rt |
Background
MG53, also known as TRIM72, is a member of the TRIM protein family, primarily expressed in the heart and skeletal muscle. It consists of an N-terminal RING, B-box, and curly helix region, with a C-terminal SPRY domain. MG53 plays a crucial role in acute cell membrane repair, anti-inflammation, stem cell regeneration, and anti-virus effects. In acute cell membrane injury, MG53 oligomerizes and recruits intracellular vesicles to the injury site, forming membrane repair patches. It also inhibits the NF-κB pathway to reduce inflammation and promotes stem cell survival and regeneration. MG53 has shown therapeutic potential in myocardial infarction, acute lung injury, and other tissue injuries.
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