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Description
Mouse Anti-Human CD184 Antibody (S-R635)Product Specification Host Mouse Antigen CD184 Synonyms C X C chemokine receptor type 4; CXC R4; CXCR 4; FB22; Fusin; HM89; LCR1; Leukocyte derived seven transmembrane domain receptor (LESTR); Lipopolysaccharide associated protein 3 (LAP 3; LPS associated protein 3); NPYRL; Stromal cell derived factor 1 receptor (SDF 1 receptor); CXCR4 Location Cell membrane Accession P61073 Clone Number S R635 Antibody Type Mouse mAb Isotype IgG2a,k Application FCM
Product Specification
| Host | Mouse |
| Antigen | CD184 |
| Synonyms | C-X-C chemokine receptor type 4; CXC-R4; CXCR-4; FB22; Fusin; HM89; LCR1; Leukocyte-derived seven transmembrane domain receptor (LESTR); Lipopolysaccharide-associated protein 3 (LAP-3; LPS-associated protein 3); NPYRL; Stromal cell-derived factor 1 receptor (SDF-1 receptor); CXCR4 |
| Location | Cell membrane |
| Accession | P61073 |
| Clone Number | S-R635 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2a,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | human PBMC |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 1:200 | Hu |
Background
CD184, also known as CXCR4, is a G protein-coupled receptor with seven transmembrane domains that serves as the receptor for stromal cell-derived factor-1 (SDF-1, also known as CXCL12). It is widely expressed in various tissues, including peripheral blood leukocytes, spleen, thymus, bone marrow, heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, cerebellum, and endothelial cells. CXCR4 plays crucial roles in multiple physiological processes, such as cell migration, hematopoiesis, vascularization, neural development, and wound healing. It also acts as a co-receptor for T-cell tropic strains of HIV-1, facilitating viral entry into CD4+ cells. In cancer, CXCR4 is overexpressed in many tumor types and is associated with increased invasiveness, metastasis, and poor prognosis. Additionally, CXCR4 is involved in the homing of hematopoietic stem cells to the bone marrow and the retention of aged neutrophils.
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Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
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