Human & Monkey CCL5 /RANTES Onestep ELISA Kit

Human CCL5 (CC Chemokine Ligand 5), previously known as RANTES (Regulated upon Activation, Normal T-cell Expressed and Secreted), is a pivotal member of the CC chemokine family characterized by its role in orchestrating immune cell migration and activation. This 8-kDa protein is secreted by a variety of cells, including T lymphocytes, platelets, macrophages, and endothelial cells, in response to inflammatory stimuli. CCL5 exerts its biological functions by binding to and signaling through multiple G-protein coupled receptors, primarily CCR1, CCR3, and CCR5. Its primary role involves the selective chemoattraction of leukocytes—such as T cells, eosinophils, basophils, and monocytes—to sites of inflammation or infection, thereby playing a critical role in both innate and adaptive immune responses. Furthermore, CCL5 is implicated in the pathogenesis of a spectrum of diseases, including autoimmune disorders, chronic inflammatory conditions, and HIV-1 infection, as it also acts as a natural ligand for CCR5, a major co-receptor for viral entry. Consequently, the CCL5-CCR5 axis represents a significant therapeutic target for immunomodulation.