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Description
PD-L1 His Tag Protein, HumanProduct Specification Species Human Synonyms Programmed cell death 1 ligand 1, CD274, B7 H1, Programmed death ligand 1 Accession Q9NZQ7 Amino Acid Sequence Phe19 Arg238, with C terminal His Tag Expression System HEK293 Molecular Weight 30 35 KD(Reducing) Purity 95%, by SDS PAGE under reducing conditions Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH 7. 2,5% trehalose
Product Specification
| Species | Human |
| Synonyms | Programmed cell death 1 ligand 1, CD274, B7-H1, Programmed death ligand 1 |
| Accession | Q9NZQ7 |
| Amino Acid Sequence | Phe19-Arg238, with C-terminal His Tag |
| Expression System | HEK293 |
| Molecular Weight | 30-35 KD(Reducing) |
| Purity | ＞95%, by SDS-PAGE under reducing conditions |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH 7.2,5% trehalose |
| Reconstitution | Reconstitute at less than 1 mg/mL according to the size in ultrapure water after rapid centrifugation . |
| Stability & Storage |
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
Background
PD-L1, also known as B7-H1 and CD274, is a 290 amino acid transmembrane glycoprotein in the B7 family of immune regulatory molecules. It has an extracellular domain that can interact with PD-1, which belongs to the CD28/CTLA4 family expressed on activated lymphoid cells. The PD1/PD-L1 interaction ensures that activation of the immune system occurs at the appropriate time. This will minimize the possibility of chronic autoimmune inflammation. PD-L1 is known to inhibit proliferation of T cells via apoptosis. It also plays an important role in arresting cell-cycle progression. This makes PD-L1 an attractive therapeutic target for cancer and immunologic diseases.
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