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Description
TEL1 Recombinant Rabbit mAb (S-3067-60)Product Specification Host Rabbit Antigen TEL1 Synonyms Transcription factor ETV6; ETS translocation variant 6; ETS related protein Tel1 (Tel); TEL; ETV6 Immunogen Synthetic Peptide Location Nucleus Accession P41212 Clone Number S 3067 60 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC, IF Reactivity Hu, Ms, Rt, Mk Positive Sample Raji, THP 1, U 2 OS, A431, HeLa, NIH 3T3, PC 12, COS 7 Purification Protein A Concentration 0. 5 mg
Product Specification
| Host | Rabbit |
| Antigen | TEL1 |
| Synonyms | Transcription factor ETV6; ETS translocation variant 6; ETS-related protein Tel1 (Tel); TEL; ETV6 |
| Immunogen | Synthetic Peptide |
| Location | Nucleus |
| Accession | P41212 |
| Clone Number | S-3067-60 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC, IF |
| Reactivity | Hu, Ms, Rt, Mk |
| Positive Sample | Raji, THP-1, U-2 OS, A431, HeLa, NIH/3T3, PC-12, COS-7 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:5000 | Hu, Ms, Rt, Mk |
| IHC-P | 1:100 | Hu, Ms, Rt |
| ICC | 1:500 | Hu, Ms |
| IF | 1:100 | Hu |
Background
TEL1 protein is the budding-yeast ortholog of mammalian ATM, a PIKK-family kinase recruited to DNA double-strand breaks by the Mre11-Rad50-Xrs2 (MRX) complex, where it phosphorylates multiple SQ/TQ motifs to launch the DNA-damage checkpoint, controls telomere length, stabilizes MRX at DSB ends independently of its catalytic activity to promote end-tethering and repair by both homologous recombination and non-homologous end-joining, and can be further activated through direct interaction with phosphoinositides such as PI(4)P.
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