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Description
Human NNMT Protein, His TagProduct Specification Species Human Synonyms Nicotinamide N methyltransferase, NNMT Accession P40261 Amino Acid Sequence Protein sequence (P40261, Met1 Leu264, with C His Tag) MESGFTSKDTYLSHFNPRDYLEKYYKFGSRHSAESQILKHLLKNLFKIFCLDGVKGDLLIDIGSGPTIYQLLSACESFKEIVVTDYSDQNLQELEKWLKKEPEAFDWSPVVTYVCDLEGNRVKGPEKEEKLRQAVKQVLKCDVTQSQPLGAVPLPPADCVLSTLCLDAACPDLPTYCRALRNLGSLLKPGGFLVIMDALKSSYYMIGEQKFSSLPLGREAVEAAVKEAGYTIEWFEVISQSYSSTMANNEGLFSLVARKLSRPL Expression
Product Specification
| Species | Human |
| Synonyms | Nicotinamide N-methyltransferase, NNMT |
| Accession | P40261 |
| Amino Acid Sequence | Protein sequence (P40261, Met1-Leu264, with C-His Tag) MESGFTSKDTYLSHFNPRDYLEKYYKFGSRHSAESQILKHLLKNLFKIFCLDGVKGDLLIDIGSGPTIYQLLSACESFKEIVVTDYSDQNLQELEKWLKKEPEAFDWSPVVTYVCDLEGNRVKGPEKEEKLRQAVKQVLKCDVTQSQPLGAVPLPPADCVLSTLCLDAACPDLPTYCRALRNLGSLLKPGGFLVIMDALKSSYYMIGEQKFSSLPLGREAVEAAVKEAGYTIEWFEVISQSYSSTMANNEGLFSLVARKLSRPL |
| Expression System | E.coli |
| Molecular Weight | Predicted MW: 31.3 kDa Observed MW: 30 kDa |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4 with 3% trehalose. |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage | 12 months from date of receipt, -20 to -70 °C as supplied. |
Background
Nicotinamide N-methyltransferase (NNMT) is a cytoplasmic enzyme that catalyzes the methylation of nicotinamide (vitamin B3) using S-adenosyl methionine (SAM) as the methyl donor, producing S-adenosylhomocysteine (SAH) and 1-methylnicotinamide (MNA). Its overexpression is implicated in various cancers, metabolic disorders, and aging, as it consumes SAM and influences global epigenetic patterns by altering the SAM:SAH ratio. NNMT is now recognized as a key metabolic enzyme with potential as a therapeutic target for cancer and obesity.
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