SKU: 80651885274

CCL21 Recombinant Rabbit mAb (S-3198-156)

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Description

CCL21 Recombinant Rabbit mAb (S-3198-156)Product Specification Host Rabbit Antigen CCL21 Synonyms C C motif chemokine 21a; 6Ckine; Beta chemokine exodus 2; Small inducible cytokine A21a; Thymus derived chemotactic agent 4 (TCA4); Ccl21a; Scya21; Scya21a Immunogen Recombinant Protein Location Secreted Accession P84444 Clone Number S 3198 156 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Ms, Rt Positive Sample mouse spleen, mouse thymus, mouse lung, rat spleen, rat

Product Specification


Host Rabbit
Antigen CCL21
Synonyms C-C motif chemokine 21a; 6Ckine; Beta-chemokine exodus-2; Small-inducible cytokine A21a; Thymus-derived chemotactic agent 4 (TCA4); Ccl21a; Scya21; Scya21a
Immunogen Recombinant Protein
Location Secreted
Accession P84444
Clone Number S-3198-156
Antibody Type Recombinant mAb
Isotype IgG
Application WB, IHC-P
Reactivity Ms, Rt
Positive Sample mouse spleen, mouse thymus, mouse lung, rat spleen, rat thymus
Purification Protein A
Concentration 0.5 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
WB 1:1000 Ms, Rt
IHC-P 1:500 Ms, Rt

Background

CCL21 (also known as secondary lymphoid tissue chemokine SLC or Exodus-2) is a CC-type chemokine of approximately 12.2 kDa consisting of 111 amino acids, encoded by the CCL21 gene on chromosome 9p13.3. Its structure is highly distinctive: although it contains a conserved chemokine domain (including the N-loop and third β-strand) and exists as a monomer, it differs from most family members by possessing six cysteines (two more than typical CC chemokines) and an exceptionally long, unstructured carboxyl-terminal tail. This C-terminal region, while not involved in canonical chemokine folding, facilitates CCL21 anchoring to the surface of lymphatic endothelial cells via glycosaminoglycan binding. Under physiological conditions, CCL21 is predominantly expressed by endothelial cells of secondary lymphoid organs such as lymph nodes, spleen, and appendix. It binds via tyrosine 12 (Y12) in its N-loop and the third β-strand to the N-terminus of the G protein-coupled receptor CCR7 with a dissociation constant of approximately 150 μM, activating downstream signaling pathways including JAK/STAT. This interaction exerts potent chemotactic effects on CCR7⁺ cells (e.g., naïve T cells and dendritic cells), driving their homing to lymphoid organs and establishing immune microenvironments. In the oncological context, however, the CCL21/CCR7 axis exhibits a pronounced double-edged sword effect: various solid tumors—including melanoma and breast cancer—hijack this homing mechanism to actively metastasize to the lymphatic system. Moreover, aberrant CCL21 expression within the primary tumor microenvironment recruits immunosuppressive cells and constructs pro-tumor lymphoid niches, directly correlating with poor prognosis in patients.

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SKU: 80651885274

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4.4 ★★★★★
Based on 8 reviews
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A
Verified Purchase
Angela L. Royer
Chelsea, US
★★★★★ 5
Great quality and indestructible
Pattern Name: Octopus Purple
My pitbull pup loves this and so far it's been indestructible. She's a very heavy chewer so it's hard to find toys that last and this one is passing the test.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 23, 2026
K
Verified Purchase
Karensen5
Pawtucket, US
★★★★★ 5
Very sturdy
Size: Large 10", Style: Rubber Dog Toy
Our Malinois cannot eat/ through this one!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 2, 2026
M
Verified Purchase
M. Miller
Dallas, US
★★★★★ 5
Not quite indestructible, but closer than other toys
Size: Large 10", Style: Rubber Dog Toy
We have a German Shepherd who chews through pretty much any toy you give him. He has very strong, destructive jaws. And, being very smart, he will find the weak point in a toy and go after it almost obsessively. He'll work tirelessly trying to chew it into submission. I don't know how many toys we've gone through. We even did the subscription where they send you indestructible toys every month. Usually, they wouldn't make it until the next shipment. Any of them. And they sent three or four in the box. Anyway, this is our second one of these. He does destroy it, but he's had this one for three months or better and it's just now really showing signs of deterioration. We'll be replacing it soon, but I'm very impressed compared to the countless other toys we've bought over the years.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on August 9, 2024
K
Verified Purchase
Keri
New York, US
★★★★★ 1
Toy Not Safe For Chewers
Size: Medium 8", Style: Rubber Dog Toy, Size: Medium 8", Style: Rubber Dog Toy
We bought this tire toy for our puppy for Christmas. It was advertised as a natural rubber dog toy and implied to be durable. It lasted less than two hours. Our puppy was able to chew off small pieces of the rubber and swallowed some of the bits, which made her extremely sick. She ended up vomiting after ingesting pieces of this toy. I would not recommend this toy, it is not safe especially for dogs that like to chew.
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Reviewed in the United States on January 14, 2026
C
Verified Purchase
Chantelle Bechtel
Draper, US
★★★★★ 5
Definitely recommend for large breed heavy chewing dogs
Size: Large 10", Style: Rubber Dog Toy
Great for a large breed dog. I got the 10inch for my large breed dog. Best choice ever.
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Reviewed in the United States on May 26, 2026

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