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Description
MYSM1 Recombinant Rabbit mAb (S-2431-114)Product Specification Host Rabbit Antigen MYSM1 Synonyms Deubiquitinase MYSM1; 2A DUB; Myb like; SWIRM and MPN domain containing protein 1; KIAA1915 Immunogen Recombinant Protein Location Cytoplasm, Nucleus Accession Q5VVJ2 Clone Number S 2431 114 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu, Mk Positive Sample A431, HeLa, Jurkat, COS 7 Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical
Product Specification
| Host | Rabbit |
| Antigen | MYSM1 |
| Synonyms | Deubiquitinase MYSM1; 2A-DUB; Myb-like; SWIRM and MPN domain-containing protein 1; KIAA1915 |
| Immunogen | Recombinant Protein |
| Location | Cytoplasm, Nucleus |
| Accession | Q5VVJ2 |
| Clone Number | S-2431-114 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu, Mk |
| Positive Sample | A431, HeLa, Jurkat, COS-7 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Mk |
Background
MYSM1 (Myb-like, SWIRM and MPN domain-containing protein 1) is a metalloprotease deubiquitinase that removes monoubiquitin from histone H2A at K119, functioning as a transcriptional coactivator by counteracting Polycomb-mediated gene silencing, and also cleaves K63-linked polyubiquitin chains from innate immune signaling molecules such as TRAF3, TRAF6, RIP2 and STING to dampen TLR, NOD2 and cGAS-STING pathways; through these dual nuclear and cytosolic activities MYSM1 regulates hematopoiesis, lymphocyte development, stem cell quiescence, inflammatory responses and tumor suppression, and its germline mutations cause a rare bone marrow failure syndrome characterized by leukopenia, anemia and multi-organ developmental defects.
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