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Description
Alexa Fluor® 647 Mouse Anti-Human CD273 Antibody (S-R590)Product Specification Host Mouse Antigen CD273 Synonyms Programmed cell death 1 ligand 2; PD 1 ligand 2; PD L2; PDCD1 ligand 2; Programmed death ligand 2; Butyrophilin B7 DC (B7 DC); B7DC; PDCD1L2; PDL2; PDCD1LG2 Location Cell membrane Accession Q9BQ51 Clone Number S R590 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Positive Sample human monocyte derived mature dendritic cells Purification Protein G Concentration 0. 05mg ml
Product Specification
| Host | Mouse |
| Antigen | CD273 |
| Synonyms | Programmed cell death 1 ligand 2; PD-1 ligand 2; PD-L2; PDCD1 ligand 2; Programmed death ligand 2; Butyrophilin B7-DC (B7-DC); B7DC; PDCD1L2; PDL2; PDCD1LG2 |
| Location | Cell membrane |
| Accession | Q9BQ51 |
| Clone Number | S-R590 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | human monocyte-derived mature dendritic cells |
| Purification | Protein G |
| Concentration | 0.05mg/ml |
| Conjugation | Alexa Fluor® 647 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 5 μl per million cells in 100μl volume | Hu |
Background
CD273, also known as B7-DC or PD-L2, is a 42 kDa type I transmembrane glycoprotein belonging to the B7 family of the immunoglobulin superfamily. It is primarily expressed in dendritic cells, liver, and a few transformed cell lines. CD273 acts as a ligand for the coinhibitory receptor PD-1 (CD279), playing a crucial role in immune regulation by inhibiting T cell activation, proliferation, and cytokine production. Unlike PD-L1, CD273 has a higher affinity for PD-1 and is particularly upregulated in the presence of Th2 cytokines such as IL-4. Additionally, CD273 can also bind to repulsive guidance molecule b (RGMb), which is involved in regulating immune responses through BMP and neogenin signaling pathways.
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Exchange/Return Notes
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