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Description
FITC Mouse Anti-Human CD59 Antibody (S-R567)Product Specification Host Mouse Antigen CD59 Synonyms CD59 glycoprotein; 1F5 antigen; 20 kDa homologous restriction factor (HRF 20; HRF20); MAC inhibitory protein (MAC IP); MEM43 antigen; Membrane attack complex inhibition factor (MACIF); Membrane inhibitor of reactive lysis (MIRL); Protectin; MIC11; MIN1; MIN2; MIN3; MSK21 Location Secreted, Cell membrane Accession P13987 Clone Number S R567 Antibody Type Mouse mAb Isotype IgG2a Application FCM
Product Specification
| Host | Mouse |
| Antigen | CD59 |
| Synonyms | CD59 glycoprotein; 1F5 antigen; 20 kDa homologous restriction factor (HRF-20; HRF20); MAC-inhibitory protein (MAC-IP); MEM43 antigen; Membrane attack complex inhibition factor (MACIF); Membrane inhibitor of reactive lysis (MIRL); Protectin; MIC11; MIN1; MIN2; MIN3; MSK21 |
| Location | Secreted, Cell membrane |
| Accession | P13987 |
| Clone Number | S-R567 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2a |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | human peripheral blood |
| Purification | Protein A |
| Concentration | 0.05mg/ml |
| Conjugation | FITC |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD59, also known as the membrane attack complex inhibition factor (MACIF), is a membrane-bound protein that plays a critical role in the regulation of the complement system, which is part of the immune system. It is the primary inhibitor of membrane attack complex (MAC) formation. It prevents the formation of pores in the membranes of cells, thereby protecting them from complement-mediated lysis. CD59 inhibits the formation of MAC by binding to C8 and/or C9, which are components of the complement system. This binding prevents the recruitment of additional C9 molecules into the complex, thus inhibiting the formation of the pore. CD59 deficiency can lead to conditions such as paroxysmal nocturnal hemoglobinuria (PNH), which is characterized by intravascular hemolysis and hemoglobinuria. Low levels of CD59 are also associated with autoimmune diseases like diabetes and multiple sclerosis.
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