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Description
Histone H3 (tri methyl K27) Recombinant Rabbit mAb (S-4331)Product Specification Host Rabbit Antigen Histone H3 (tri methyl K27) Synonyms H3K27me3 Location Nucleus Accession P68431 Clone Number S 4331 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Rt, Mk Positive Sample HeLa, Jurkat, NIH 3T3, COS 7 Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin 300
Product Specification
| Host | Rabbit |
| Antigen | Histone H3 (tri methyl K27) |
| Synonyms | H3K27me3 |
| Location | Nucleus |
| Accession | P68431 |
| Clone Number | S-4331 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt, Mk |
| Positive Sample | HeLa, Jurkat, NIH/3T3, COS-7 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:500-1:1000 | Hu, Ms, Mk |
| IHC-P | 1:1000 | Hu, Ms, Rt |
| ICC | 1:1000 | Hu, Ms |
Background
Histone H3 (tri methyl K27) (H3K27me3) is a crucial epigenetic modification catalyzed by the Polycomb Repressive Complex 2 (PRC2). It functions primarily in the transcriptional repression of target genes and plays a key role in biological processes such as embryonic development, cell fate determination, and genomic imprinting. It is particularly vital for maintaining stem cell pluripotency and establishing cell type-specific gene expression patterns. Aberrant distribution of H3K27me3 is associated with various diseases, including developmental disorders and cancers (such as certain sarcomas and lymphomas), where its excessive silencing can lead to the inactivation of tumor suppressor genes. Common techniques for detecting H3K27me3 include ChIP-seq and immunofluorescence. Furthermore, it is a significant target for current epigenetic drug development, such as EZH2 inhibitors.
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