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Description
GFRAL Fc Chimera Protein, HumanProduct Specification Species Human Synonyms GFR alpha like,GRAL,GDNF family receptor alpha like Accession Q6UXV0 Amino Acid Sequence Ser19 Glu351 with Human IgG1 Fc at the C Terminus Expression System HEK293 Molecular Weight 60 80kDa (Reducing) Purity 95% by SDS PAGE &SEC HPLC Conjugation Unconjugated Tag Human IgG1 Fc Physical Appearance Lyophilized Powder Storage Buffer PBS, PH7. 4, 5% trehalose Reconstitution Reconstitute at 0. 1 1 mg ml according
Product Specification
| Species | Human |
| Synonyms | GFR alpha like,GRAL,GDNF family receptor alpha-like |
| Accession | Q6UXV0 |
| Amino Acid Sequence | Ser19-Glu351 with Human IgG1 Fc at the C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 60-80kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE &SEC-HPLC |
| Conjugation | Unconjugated |
| Tag | Human IgG1 Fc |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | 1.Airaksinen MS, Holm L, Hätinen T. Evolution of the GDNF family ligands and receptors. Brain Behav Evol. 2006;68(3):181-90. |
Background
GFR alpha-like is also known as GDNF family receptor alpha-like, GFRAL, C6orf144, UNQ9356, PRO34128. Macrophage inhibitory cytokine-1/growth differentiation factor 15 (MIC-1/GDF15) is a divergent transforming growth factor (TGFbeta) superfamily cytokine implicated in biological and disease processes including metabolism, cancer, and chronic inflammation. GDNF family receptor α-like (GFRAL) was recently identified as the neuronal brainstem receptor responsible for mediating the anorectic actions of GDF15. Brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses . Upon interaction with its ligand, GDF15, interacts with RET and induces cellular signaling through activation of MAPK- and AKT- signaling pathways.
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