SKU: 82477940544

FITC Rat Anti-Mouse Ig, κ Light Chain Antibody (S-4252)

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Description

FITC Rat Anti-Mouse Ig, κ Light Chain Antibody (S-4252)Product Specification Host Rat Antigen Ig, Light Chain Synonyms Immunoglobulin kappa constant; Igkc Location Cell membrane Accession P01837 Clone Number S 4252 Antibody Type Rat mAb Isotype IgG1,k Application FCM Reactivity Ms Purification Protein G Concentration 0. 5 mg ml Conjugation FITC Physical Appearance Liquid Storage Buffer PBS, 1% BSA, 0. 3% Proclin 300 Stability & Storage 12 months from date of receipt reconstitution, 2 to 8 C as supplied

Product Specification


Host Rat
Antigen Ig, κ Light Chain
Synonyms Immunoglobulin kappa constant; Igkc
Location Cell membrane
Accession P01837
Clone Number S-4252
Antibody Type Rat mAb
Isotype IgG1,k
Application FCM
Reactivity Ms
Purification Protein G
Concentration 0.5 mg/ml
Conjugation FITC
Physical Appearance Liquid
Storage Buffer

PBS, 1% BSA, 0.3% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Background

Immunoglobulin kappa (Igκ) light chains are one of the two types of polypeptide chains, alongside lambda chains, that constitute the antigen-binding fragment of antibodies in humans and many other mammals, playing a critical role in the adaptive immune system's ability to recognize diverse pathogens. Each antibody molecule typically comprises two identical heavy chains and two identical light chains, where the kappa light chain consists of a variable domain (Vκ) responsible for antigen specificity through hypervariable complementarity-determining regions (CDRs), and a constant domain (Cκ) that provides structural stability and facilitates proper folding and assembly with the heavy chain within the endoplasmic reticulum of B cells. In humans, the immunoglobulin light chain locus is located on chromosome 2, and during B cell development, V-J recombination generates immense diversity in the Vκ region, allowing the immune system to produce billions of unique antibodies; notably, each B cell expresses exclusively either kappa or lambda light chains, a phenomenon known as allelic exclusion, which ensures monospecificity, with kappa chains being more prevalent than lambda chains in human serum at an approximate ratio of 60:40. Clinically, the detection of free kappa light chains or an abnormal kappa-to-lambda ratio is a vital diagnostic marker for B-cell malignancies such as multiple myeloma and light chain amyloidosis, as clonal proliferation often results in the overproduction of a single type of light chain that can be measured in blood or urine to monitor disease progression and treatment response.

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SKU: 82477940544

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4.4 ★★★★★
Based on 27 reviews
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B. B.
Lake Worth, US
★★★★★ 5
Very pleased with these!
Size: 9, Color: Egret/Lavender/Multi
I wasn't sure about these, but have had good luck with other HEYDUDE shoes. So I ordered these. True to size. I'm pleasantly surprised. Very comfortable and cute. They don't look like the usual HEYDUDE frumpy shoes. But yet they provide the same comfort as frumpy HEYDUDES. (Nothing against frumpy HEYDUDES. I own a pair and wear them for comfort.)
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Reviewed in the United States on April 4, 2026
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Verified Purchase
noah
Port Orchard, US
★★★★★ 1
Runs large and too squishy of a sole
Size: 9, Color: Black/White
Why did you pick this product vs others?: I really wanted to love these, but the fit was off, and the sole is extremely squishy, which on a platform shoe was nearly a disaster.  I wear an 8.5/9 in all my shoes. I got a size 9, and they were far too big. I also have wide feet and the straps still had excess room between the strap and the tops of my feet.  I tried the shoes on, took a few steps, and the sole was so squishy it felt like I was falling. If I had a size 8, instead of 9, maybe that would not have happened.  I ended up returning, but wish the fit was better as these are super cute shoes 
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Reviewed in the United States on June 19, 2025
J
Verified Purchase
Jose Correa
Dallas, US
★★★★★ 5
Stunning Automatic Watch With TopTier Durability and Precision
Color: Grey
“I got this Tissot PRX for my cousin’s birthday and bro fell in LOVE instantly. This thing keeps time like a beast, never slows down, never lags. Automatic movement, so no batteries, no drama. Durability? Stupid good. You can hit it, bump it, live life rough, it still looks box fresh. Size wise it was almost perfect. I just had to remove two links, nothing big. It’s light, functional, comfortable, doesn’t weigh you down, doesn’t get in the way but more importantly I can say this watch is in everyone’s eyesight when we wear it. Cause of course I had to get another one! Basically. I gave him a very nice piece as a gift, and now he’s walking around like he owns Switzerland.
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Reviewed in the United States on December 11, 2025
C
Verified Purchase
Cienfuegos
Charlottesville, US
★★★★★ 5
Great watch!!!!
Color: Grey
Excellent quality, one of the best, elegant.
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Reviewed in the United States on May 6, 2026
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Verified Purchase
T. H.
Charlottesville, US
★★★★★ 5
Excellent value for an automatic watch, keeps VERY good time.
Color: Grey, Color: Grey
I've only had the watch for a day but wanted to leave a quick review on it to share a couple of notes. So far it keeps VERY good time, better than any of the automatics I own (including a Rolex Submariner, Tag Heuer Aquaracer, Tag Heuer Formula One, and several other sub $1k watches). I set it to an atomic time app on my phone yesterday and 24 hours later it's still SPOT on - hasn't gained/lost even a 1/10 of a second. I was shocked to see it's kept PERFECT time for the last day, I'm really blown away so far. I've worn it the entire time, we'll see how well it keeps time while being stored in a winder. This picture shown is the watch with a 22mm leather band on it, fit's without any issues (just need to squeeze in the leather a tad). I doubt it would work with a 22mm metal bracelet, but leather works great. Just FYI since the 21mm lug width is kind of odd. The face isn't quite a lustrious as the images make it look, but it's still a great-looking watch. For a sub $1000 automatic you can't go wrong, this is a fantastic watch at a great price. It'll be my daily driver for some time I'm sure. If I have any issues in the future I'll update the review.
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Reviewed in the United States on March 22, 2021

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