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Description
MAFA Recombinant Rabbit mAb,PBS Only (SDT-2040-6)Product Specification Host Rabbit Antigen MAFA Synonyms Transcription factor MafA; Pancreatic beta cell specific transcriptional activator; RIPE3b1 factor; V maf musculoaponeurotic fibrosarcoma oncogene homolog A Immunogen Synthetic Peptide Location Nucleus Accession Q8NHW3 Clone Number SDT 2040 6 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu, Ms, Rt Positive Sample Beta TC 6 Purification Protein A Concentration 1 mg ml
Product Specification
| Host | Rabbit |
| Antigen | MAFA |
| Synonyms | Transcription factor MafA; Pancreatic beta-cell-specific transcriptional activator; RIPE3b1 factor; V-maf musculoaponeurotic fibrosarcoma oncogene homolog A |
| Immunogen | Synthetic Peptide |
| Location | Nucleus |
| Accession | Q8NHW3 |
| Clone Number | SDT-2040-6 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | Beta-TC-6 |
| Purification | Protein A |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS |
| Stability & Storage | 12 months from date of receipt / reconstitution, 4 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| IHC-P | 1:200 | Hu, Ms, Rt |
Background
The MAFA protein (Musculoaponeurotic Fibrosarcoma Oncogene Homolog A) is a member of the basic leucine zipper (bZIP) transcription factor family, primarily expressed in pancreatic β-cells, the retina, and lymphocytes. It plays a critical role in regulating the transcription of the insulin gene (INS) by binding to the C1 element in the insulin gene promoter region, thereby promoting insulin synthesis and secretion to maintain glucose homeostasis. The expression and activity of MAFA are regulated by various factors, including glucose concentration, cytokines, and oxidative stress. In diabetes research, dysfunction of MAFA is closely associated with β-cell dysfunction and impaired insulin secretion, making it a potential therapeutic target. Additionally, MAFA also plays important roles in retinal development and immune regulation.
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