SKU: 83017184523

IL-23 R Fc Chimera Protein, Human

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Description

IL-23 R Fc Chimera Protein, HumanProduct Specification Species Human Synonyms IBD17,IL 23 receptor Accession Q5VWK5 1 Amino Acid Sequence Gly24 Gly355 with hIgG1 Fc at the C Terminus Expression System HEK293 Molecular Weight 90 110kDa (Reducing) Purity 95% by SDS PAGE & HPLC Conjugation Unconjugated Tag Human IgG1 Fc Physical Appearance Lyophilized powder Storage Buffer PBS, PH7. 4, 5% trehalose Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water

Product Specification


Species Human
Synonyms IBD17,IL-23 receptor
Accession Q5VWK5-1
Amino Acid Sequence

Gly24-Gly355 with hIgG1 Fc at the C-Terminus
Expression System HEK293
Molecular Weight

90-110kDa (Reducing)
Purity ＞95% by SDS-PAGE & HPLC
Conjugation Unconjugated
Tag Human IgG1 Fc
Physical Appearance Lyophilized powder
Storage Buffer

PBS, PH7.4, 5% trehalose
Reconstitution

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference

1.Benson JM, Sachs CW, Treacy G, Zhou H, Pendley CE, Brodmerkel CM, Shankar G, Mascelli MA. Therapeutic targeting of the IL-12/23 pathways: generation and characterization of ustekinumab. Nat Biotechnol. 2011 Jul;29(7):615-24.
2.Hue S, Ahern P, Buonocore S, Kullberg MC, Cua DJ, McKenzie BS, Powrie F, Maloy KJ. Interleukin-23 drives innate and T cell-mediated intestinal inflammation. J Exp Med. 2006 Oct 30;203(11):2473-83.

Background

Interleukin-23 (IL-23) is a heterodimeric cytokine composed of p19 and p40 subunits. Its functional receptor, IL-23R, combines with the IL-12Rβ1 subunit to form a type I cytokine receptor complex. This complex activates the downstream JAK2-STAT3 signaling pathway, regulating the proliferation, differentiation, and secretion of inflammatory factors in immune cells such as T cells and NK cells. It plays a central role in sustaining Th17 cell-mediated inflammatory responses. Clinically, abnormal activation of the IL-23/IL-23R pathway is a key pathogenic mechanism in autoimmune diseases such as psoriasis and inflammatory bowel disease. Additionally, it promotes tumorigenesis within the tumor microenvironment, making it a critical therapeutic target.
Shipping Notes
  • Free Standard Shipping on $100+ Orders to the USA.
  • Except Preorder products are shipped in 48 hours.
  • Delivery to the USA:
  1. Standard Shipping : 3-10 business days
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Exchange/Return Notes
  • We offer a 30-day return/exchange service after receiving.
  • Final sale items are not eligible for returns or exchanges.
  • To process your return/exchange, please contact us at [email protected]
  • Please click here for more details>>> Return & Exchange Policy
SKU: 83017184523

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4.6 ★★★★★
Based on 7 reviews
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Product Reviews
L
Verified Purchase
Larry B.11
Boise, US
★★★★★ 5
Quality jewelry box for the price
Color: Beige, Size: 2-Layer, Color: Beige, Size: 2-Layer
I needed a nice jewelry box for a small space. This was perfect for my needs. It holds a nice amount of jewelry. I would recommend this jewelry box. It was also nicely packaged for a gift as well.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 3, 2026
S
Verified Purchase
Susan L Van Eyck
Belleville, US
★★★★★ 5
Attractive, well-made functional storage
Color: Dusty Blue, Size: 2 Layers, 20 Hooks
I'm quite happy with this product. It's an orderly and attractive way to store a lot of jewelry. I've put my favorites in the visible front drawer and can easily see the rest by pulling out the back drawer. I looked at a similar storage box with see-through panels on both sides, but it didn't look quite as well made and you'd have to turn it around to see side B (i.e., no less work than pulling out the back drawer). This unit feels well put together, looks nice, and sits stably on top my dresser. I'm only using it for chain-and-pendant style necklaces (leaving the bulkier stuff in an upright acrylic spoke-style container) but have it fully loaded and have doubled up on a few pegs. None of the pegs bent while I was adding pieces.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 28, 2026
M
Verified Purchase
Michelle M
San Leandro, US
★★★★★ 5
Fantastic Necklace Organiser
Color: White, Size: 2 Layers, 20 Hooks
This is a great necklace organiser It has helped me keep all my necklaces in order - putting gold on one tray and silver the other. Keeps them for getting all tangled up and looks super nice. Not to mention the slim design doesn’t take up much space. Love it!!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 28, 2026
L
Verified Purchase
Lisko
Chelsea, US
★★★★★ 5
Great necklace organizer!
Color: White, Size: 2 Layers, 20 Hooks
This necklace organizer is perfect for keeping necklaces separated and in view. I was tired of having them tangled in my jewelry box and this does the trick. Plus it is very well made and looks lovely in my closet. I highly recommend this for people who want to keep their necklaces organized!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 15, 2026
Z
Verified Purchase
Zilly115
Charlottesville, US
★★★★★ 5
So pretty!
Color: White, Size: 2 Layers, 20 Hooks
I got the two drawer box. Very nice quality necklace organizer. Looks beautiful with all my necklaces in it. Versatile as well as it has compartment on the bottom so that when you pull the drawer out the longer necklaces stay contained. You can also hang more than one necklace on the little hooks. I feel this will provide superb protection for my jewelry even with travel. I wish I got this sooner! It is a beautiful way to display the necklaces but I keep mine in my dresser drawer and it fits perfectly.
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Reviewed in the United States on April 11, 2026

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