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Description
Islet1 Recombinant Rabbit mAb (SDT-2349-17)Product Specification Host Rabbit Antigen Islet1 Synonyms Insulin gene enhancer protein ISL 1; Islet 1; ISL1 Immunogen Synthetic Peptide Location Nucleus Accession P61371 Clone Number SDT 2349 17 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Rt Positive Sample SH SY5Y, mouse pancreas Predicted Reactivity Zf, Ck Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid
Product Specification
| Host | Rabbit |
| Antigen | Islet1 |
| Synonyms | Insulin gene enhancer protein ISL-1; Islet-1; ISL1 |
| Immunogen | Synthetic Peptide |
| Location | Nucleus |
| Accession | P61371 |
| Clone Number | SDT-2349-17 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | SH-SY5Y, mouse pancreas |
| Predicted Reactivity | Zf, Ck |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:2000 | Hu, Ms |
| IHC-P | 1:250 | Hu, Ms, Rt |
| ICC | 1:100 | Hu |
Background
Islet1 is a transcription factor protein that plays a crucial role in the development and differentiation of various cell types, particularly in the nervous system and the pancreas. In the nervous system, it is involved in the specification and maturation of motor neurons and interneurons, helping to guide their proper formation and function during embryonic development. In the pancreas, Islet1 is essential for the development of endocrine cells, including those that produce insulin and other hormones. Its expression is tightly regulated and its dysfunction has implicated been in developmental disorders and diseases such as diabetes.
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Exchange/Return Notes
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