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Description
Histone H3.3 Recombinant Rabbit mAb (S-3883)Product Specification Host Rabbit Antigen Histone H3. 3 Synonyms H3. 3A; H3F3; H3F3A; H3 3A Location Nucleus Accession P84243 Clone Number S 3883 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC, ChIP Reactivity Hu, Ms, Rt, Mk Positive Sample Ramos, Raji, HeLa, PC 3, NIH 3T3, mouse colon, rat stomach, COS 7 Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40%
Product Specification
| Host | Rabbit |
| Antigen | Histone H3.3 |
| Synonyms | H3.3A; H3F3; H3F3A; H3-3A |
| Location | Nucleus |
| Accession | P84243 |
| Clone Number | S-3883 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC, ChIP |
| Reactivity | Hu, Ms, Rt, Mk |
| Positive Sample | Ramos, Raji, HeLa, PC-3, NIH/3T3, mouse colon, rat stomach, COS-7 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt, Mk |
| IHC-P | 1:2000 | Hu, Ms, Rt |
| ICC | 1:500 | Hu |
| ChIP | 1:20-1:50 | Hu |
Background
Histone H3.3 is a replication-independent variant of the canonical histone H3 that can be deposited into nucleosomes throughout the cell cycle by dedicated chaperones such as HIRA, DAXX/ATRX, and DEK; it plays pivotal roles in gene activation, epigenetic memory, and chromatin remodeling because its distinct amino-acid sequence—especially residues that differ from H3.1/H3.2 like Ser31, Ala87, and Val89—alters nucleosome stability and creates preferential binding surfaces for transcription factors and histone-modifying enzymes, thereby influencing processes ranging from stem-cell pluripotency and development to neuronal activity and oncogenesis when its incorporation or mutations (e.g., the oncohistone Gly34Arg or Lys27Met) become dysregulated.
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