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Description
Invivo Anti-Human IFN-γ Recombinant mAbProduct Specification Host Mouse Antigen IFN Synonyms Interferon gamma; IFN gamma; Immune interferon; IFNG Location Secreted Accession P01579 Clone Number S 3076 1 Antibody Type Recombinant mAb Isotype IgG1,k Application WB, in vitro IFN neutralization, in vivo IFN neutralization in humanized mice Reactivity Hu Purification Protein G Concentration 5 mg ml Purity >95%(Determined by SDS PAGE) Endotoxin <1EU mg Conjugation Unconjugated Physical
Product Specification
| Host | Mouse |
| Antigen | IFN-γ |
| Synonyms | Interferon gamma; IFN-gamma; Immune interferon; IFNG |
| Location | Secreted |
| Accession | P01579 |
| Clone Number | S-3076-1 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG1,k |
| Application | WB, in vitro IFNγ neutralization, in vivo IFNγ neutralization in humanized mice |
| Reactivity | Hu |
| Purification | Protein G |
| Concentration | 5 mg/ml |
| Purity | >95%(Determined by SDS-PAGE) |
| Endotoxin | <1EU/mg |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, containing no preservative |
| Stability & Storage | 2 to 8 °C for 2 weeks under sterile conditions; |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
Background
Interferon gamma (IFN-γ) is a dimerized soluble cytokine and the only member of the type II class of interferons. It is primarily produced by CD4+ T helper 1 (Th1) cells, natural killer (NK) cells, and CD8+ cytotoxic T cells. The IFN-γ protein is encoded by the IFNG gene in humans and consists of approximately 160 amino acids, forming a noncovalently linked homodimer with a molecular weight of about 50 kDa. It plays a crucial role in regulating both innate and adaptive immunity by activating signaling pathways, such as the JAK-STAT pathway, in cells like macrophages and B cells. IFN-γ has antiviral, antibacterial, and antitumor properties and is involved in promoting inflammation and cell proliferation. However, its pleiotropic nature also means it can induce immunosuppressive effects, which limit its clinical use.
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