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Description
Sialoadhesin/CD169 Recombinant Rabbit mAb, PBS Only (SDT-3228-8)Product Specification Host Rabbit Antigen CD169 Synonyms Sialoadhesin; Sheep erythrocyte receptor (SER); Sialic acid binding Ig like lectin 1 (Siglec 1); Sa; Sn; Siglec1 Immunogen Recombinant Protein Location Cell membrane Accession Q62230 Clone Number SDT 3228 8 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Rt Positive Sample PMA, LPS and BFA treated THP 1 cells, LPS treated RAW264. 7, mouse spleen, mouse
Product Specification
| Host | Rabbit |
| Antigen | CD169 |
| Synonyms | Sialoadhesin; Sheep erythrocyte receptor (SER); Sialic acid-binding Ig-like lectin 1 (Siglec-1); Sa; Sn; Siglec1 |
| Immunogen | Recombinant Protein |
| Location | Cell membrane |
| Accession | Q62230 |
| Clone Number | SDT-3228-8 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | PMA, LPS and BFA treated THP-1 cells, LPS treated RAW264.7, mouse spleen, mouse liver, rat spleen, rat liver |
| Purification | Protein A |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS |
| Stability & Storage | 12 months from date of receipt / reconstitution, 4 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:5000 | Hu, Ms, Rt |
| IHC-P | 1:1000 | Hu, Ms, Rt |
| ICC | 1:500 | Ms |
Background
CD169, also known as Siglec-1 or sialoadhesin, is a type I transmembrane glycoprotein of the immunoglobulin superfamily expressed predominantly on subsets of tissue-resident macrophages and some dendritic cells; it contains 17 extracellular Ig-like domains that together project ~33 nm from the plasma membrane to enable high-avidity binding to α2,3-linked sialic acid moieties on glycoproteins and glycolipids of host cells or pathogens, thereby facilitating pathogen capture, antigen presentation, and adaptive immune priming while simultaneously serving as an entry portal for viruses such as HIV-1, PRRSV, and SARS-CoV-2, and its interferon-inducible expression correlates with both protective immunity and disease severity in infections, cancer, and chronic inflammatory disorders.
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4.1 ★★★★★
Based on 12 reviews
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Product Reviews
★★★★★ 4
A new take 🤔
Format: Kindle
I’m not going to go into what this book is about — by now you e already read the synopsis and have an idea — but I will give a couple of insights.
Definitely a different take on angels and their fall; I like it. This is an interesting start to a new series - YES, this does end on a cliffhanger so be prepared for that. I’m eager for the next book (and hopefully the last in this series — sometimes the author(s) will switch it up depending on how the story flows for them) in this series.
I’m hoping that a certain male character redeems himself because he’s a dick that will make the meaning of mixed signals jealous lol.
You ever watch that old movie — I think it’s call Mommy Dearest? — yea, let’s switch that up to daddy. That man would make a perfect husband to mommy dearest.
I recommend this book because while these authors are well known for their cliffhangers, they are also well known for putting out good stories.
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Reviewed in the United States on February 19, 2024
★★★★★ 3
Liked it
Format: Kindle
I liked the worlds and the characters. The prophesy is confusing in that I would think, since all worlds ore on a path to destruction, the angels would want their world to be saved. I am sure there is more evil that will be revealed as the series proceeds. I dislike a prolonged “poor little me” trope and the main character has moved past that, thankfully, and began to show a fierce attitude as the novel progressed. The last portion of the novel had some great action. It’s worth reading, just be patient with a slow start.
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Reviewed in the United States on February 14, 2024
★★★★★ 5
Unexpectedly emotional and packed with action!
Format: Kindle
Why do I suddenly want nothing more than a tiny wyvern to snuggle with?! It’s adorable and I absolutely love all of those moments! Wings of Stars was everything I’ve come expect from this powerful author duo. The fact that it’s written by two different people is completely transparent to the reader and they’ve brought us another world and characters that we’re all emotionally connected to and fully invested in! The injustice that we see from Alfemir in the many forms in which it comes is infuriating and makes me desperate for the conclusion of the story so they can all get what’s coming to them! I love all the guys right now, with one exception, and if you’re read it, you know exactly who I’m talking about. Bastian is hilarious - he was the comedic relief through an otherwise quite serious story. My heart bleeds for him and I can’t wait to see how he progresses through the series. Parts of Wings of Stars were unexpectedly emotional and of course I was left with my jaw on the floor at that cliffhanger! Next, please!
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Reviewed in the United States on October 18, 2025
★★★★★ 5
Niz !!!
Format: Kindle
First, let me say that I love both of these authors. I have been hooked by both ever since I discovered their writings, and I follow their social media groups closely. This book did not disappoint. Sure, there are several questions that I have, a couple of times I went huh (which I won't get into because I do not want to offer any spoilers) and I hated the cliff hanger lol, but I cannot lie and say I didn't love the book, because I did. The twist on angels was new and fresh, even though that is part of my questions. The beginning and ending were the better parts, the middle was needed but sorta bogged a little. Kieran was confusing but relatable. Niz is BY FAR the best character of the book, love NIZ. For me, Bastian is a close second, always loved the crazy ones. The other men were good, but Steele gets on my nerves and as of right now, IMO, he doesn't belong, but we will see how that goes. I have lots of questions, but this was an excellent start to a new series and I cannot wait for the next book. Highly recommend
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Reviewed in the United States on February 21, 2024
★★★★★ 4
fallen destiny? more like destined to fall in love
Format: Kindle
Kieran is an angel, but she doesn't have an affinity. Nothing angers her father more. If she doesn't find an affinity soon she will be cast to earth & have her wings removed. But she has the choice to become a fallen angel, wings turn black, & live her life on edge.
Towards the end of the book things start to make sense. Gabe’s nickname for Kieran, Steele’a hatred, Bastian’s belief that Kieran is powerful. This book ended literally during a war? As one of her friends was injured, and admitted a bit secret? Talk about cliff hanger. The next book comes out August 5th.
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Reviewed in the United States on July 8, 2024
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