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Description
FITC Mouse Anti-Human CD11a/CD18 Antibody (S-2969)Product Specification Host Mouse Antigen CD11a CD18 Synonyms Integrin alpha L; CD11 antigen like family member A; Leukocyte adhesion glycoprotein LFA 1 alpha chain (LFA 1A); Leukocyte function associated molecule 1 alpha chain; ITGAL; CD11A; Integrin beta 2; Cell surface adhesion glycoproteins LFA 1 CR3 p150,95 subunit beta; Complement receptor C3 subunit beta; ITGB2; MFI7 Location Cell membrane Accession P05107P20701 Clone Number S 2969 Antibody Type
Product Specification
| Host | Mouse |
| Antigen | CD11a/CD18 |
| Synonyms | Integrin alpha-L; CD11 antigen-like family member A; Leukocyte adhesion glycoprotein LFA-1 alpha chain (LFA-1A); Leukocyte function-associated molecule 1 alpha chain; ITGAL; CD11A; Integrin beta-2; Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta; Complement receptor C3 subunit beta; ITGB2; MFI7 |
| Location | Cell membrane |
| Accession | P05107、P20701 |
| Clone Number | S-2969 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | PMA treated human peripheral blood granulocytes |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | FITC |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD11a/CD18, also known as Lymphocyte Function-associated Antigen-1 (LFA-1), is a heterodimeric integrin predominantly expressed on the surface of all leukocytes, consisting of an alpha chain (CD11a) and a beta chain (CD18) linked by non-covalent bonds, and belongs to the β2 integrin family. As a critical adhesion molecule in the immune system, LFA-1 primarily mediates firm adhesion between leukocytes and vascular endothelial cells or other immune cells, a process essential for leukocyte migration from the bloodstream into inflamed or infected tissues (extravasation). Its mechanism involves specific binding to ligands such as Intercellular Adhesion Molecules (ICAM-1, ICAM-2, etc.), which is regulated by "inside-out" signaling that induces rapid conformational changes upon cell activation, shifting the molecule from a low-affinity to a high-affinity state to strengthen binding. Furthermore, CD11a/CD18 plays a central role in immunological synapse formation, T cell activation and proliferation, cytotoxic T cell-mediated killing of target cells, and neutrophil phagocytosis; functional defects lead to Leukocyte Adhesion Deficiency type 1 (LAD-1), characterized by recurrent bacterial infections and impaired wound healing, while its hyperactivation is associated with various autoimmune diseases and chronic inflammation, making it a significant target for anti-inflammatory drug development.
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Exchange/Return Notes
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