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Description
4-1BB Ligand/TNFSF9 Fc Chimera Protein, HumanProduct Specification Species Human Synonyms 4 1BB Ligand, TNFSF9, CD137L Accession P41273 1 Concentration 95% by SDS PAGE Amino Acid Sequence Arg71 Glu254, with N terminal Fc Expression System HEK293 Molecular Weight 43 55kDa (Reducing) Endotoxin <0. 1EU g Conjugation Unconjugated Tag Human IgG1 Fc Physical Appearance Lyophilized Powder Storage Buffer PBS, PH7. 4, 5% trehalose5% mannitol Reconstitution Reconstitute at 0. 1 1 mg ml according to the
Product Specification
| Species | Human |
| Synonyms | 4-1BB Ligand, TNFSF9, CD137L |
| Accession | P41273-1 |
| Concentration | ＞95% by SDS-PAGE |
| Amino Acid Sequence | Arg71-Glu254, with N-terminal Fc |
| Expression System | HEK293 |
| Molecular Weight | 43-55kDa (Reducing) |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | Human IgG1 Fc |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose，5% mannitol |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1.Cancer Res.2019 Feb 15;79(4):783-794. |
Background
The 4-1BB ligand (4-1BBL), also known as CD137L, is a type II transmembrane protein that is part of the TNF superfamily. 4-1BBL is the high affinity ligand of 4-1BB. Its receptor, CD137/4-1BB, is found on a variety of cells, including inflamed endothelial cells, where its expression enhances extravasation of CD137L expressing monocytes. 4-1BB Ligand is expressed by activated B cells, monocytes, macrophages, dendritic cells (DC), T cells, lymphoma and multiple myeloma cells, hematopoietic stem cells, early myeloid progenitors, neurons, and astrocytes. 4-1BBL induces the proliferation of activated peripheral blood T-cells. Also, 4-1BBL may have a role in activation-induced cell death (AICD).
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4.4 ★★★★★
Based on 16 reviews
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Product Reviews
★★★★★ 5
Great for use in Italy!
We spent 3 weeks in Italy in May of 2023. This was so easy to use for making sure all of our cell phones and power bricks were fully charged for the next day of discovery while in Italy. Plugged in effortlessly everywhere we stayed in Italy. We used all the charging ports and the USA outlets for two dual voltage power packs (remember the Italian grid is 240VAC not 120VAC like in USA) and my dual voltage CPAP power brick. No problems any where - it worked flawlessly. I would not suggest using it for curling irons or blow dryers or any very high wattage devices and anything you plug into it that does not say dual voltage on the device may be destroyed and possible catch fire! So do be aware of what you use with it as it does not drop the voltage to 120VAC from the 240VAC Italian wall outlets. Nice feature is that it comes with an adapter you can use when you get back to USA so you can use it at home till you pack your bags for the next trip!
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Reviewed in the United States on June 15, 2023
★★★★★ 5
Worked as expected, lots of USB ports.
Just used on my trip to Paris, worked well and I liked having so many USB ports. The long cord was great because my hotel was rather vintage and the outlets weren't in convenient places. Glad to see it will also work for my next trip. I appreciated that it came with adapters for the US also so I could test it at home before I left.
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Reviewed in the United States on September 28, 2025
★★★★★ 5
Perfect for travel!
These "extension cord" power adapters were perfect for us during a recent trip to Europe! They come with multiple adapters so that you can use the adapter in several countries. Best of all, one of the adapters is for North America, so we can still use them at home! Each adapter has three 3-prong plug sockets (meaning you can use either 2-prong or 3-prong plugs), one of which is set slightly apart from the other two to accommodate a larger plug. Each has four USB ports, plus one USB-C port. Plus, it has a 5-foot extension cord, so you can reach that one socket that never seems to be where you actually need it to be! That made it perfect to be able to set the adapter on the bedside table and charge all of our devices at once, but still keep our phones close at hand for checking time, setting alarms, etc. With all of that in one little box, we were able to eliminate the bag-full of various adapters we've had to pack for past trips. Definitely recommend these for your travel needs!
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Reviewed in the United States on May 22, 2024
★★★★★ 5
What an amazing adapter/outlet!
Style: Type C/G/A-Most Countries-3FT
This adapter/outlet is the best I've used for my travels (Internationally). It stands out in a crowded market with its versatility and convenience. It supports plugs from many countries, including the US, UK, EU, Asia and Africa, making it an ideal companion for travelers.
Please note: that this outlet does not convert voltage (iPhones/Tablets/Gadgets with USB connections are OK).
Design and Build Quality:
The adapter is compact and well-built, featuring a sturdy design that can withstand the rigors of travel. It fits in the of your hand (adults) and takes no luggage space at all. The 3ft cable from the outlet is helpful so that the outlet sits away from the wall allowing plenty of room on a table/stand, for multi-devices to be charged without congestion.
Functionality:
One of the standout features of this adapter is its multiple USB ports. It includes 2 USB-A and 2 USB-C port, allowing you to charge multiple devices simultaneously and quickly. This is particularly useful for charging smartphones, tablets, and other gadgets without needing multiple adapters.
Comes with 2 additional outlet attachments to be used either in UK/US/Africa/Asia
Performance:
The adapter performs exceptionally well, providing a stable and reliable connection. The USB ports offer fast charging, which is a significant advantage when you’re on the go.
Pros:
Supports plugs from many countries
Multiple USB ports (2 USB-A and 2 USB-C)
Compact and durable design
Fast charging capabilities
Cons:
None so far
Conclusion: Very happy with this International outlet that can also be used for daily usage.
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Reviewed in the United States on January 12, 2025
★★★★★ 5
Highly Recommend!
Style: Type C/G/A-Most Countries-3FT
Recently traveled from the US to London and discovered a game-changing accessory - this universal plug adapter. It was a revelation! With this handy device, we could recharge all our essentials, from iPads and iPhones to headphones, effortlessly.
The adapter's compact design and ease of use made it an indispensable companion during our trip. No more scrambling for charging stations or worrying about device compatibility. This adapter ensured we were always powered up and ready for the next day's adventures.
Whether you're a frequent international traveler or just planning a trip abroad, this universal plug adapter is a must-have. Its reliability, convenience, and versatility make it an excellent investment for anyone who wants to stay connected and charged on-the-go.
Highly recommended!
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Reviewed in the United States on March 28, 2025
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