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Description
EGFRvIII Fc Chimera Protein, HumanProduct Specification Species Human Synonyms EGFRvIII Accession NP_001333870. 1 Amino Acid Sequence Leu25 Ser378, with C terminal Human IgG1 Fc
Product Specification
| Species | Human |
| Synonyms | EGFRvIII |
| Accession | NP_001333870.1 |
| Amino Acid Sequence | Leu25-Ser378, with C-terminal Human IgG1 Fc LEEKKGNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIEGRMDPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK |
| Expression System | HEK293 |
| Molecular Weight | 80-95kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | Human Fc Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1、Gan H. et al. (2013) The epidermal growth factor receptor variant III (EGFRvIII): where wild things are altered. FEBS J. 280(21): 5350-5370. |
Background
The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human epithelial tumors, often as a consequence of gene amplification.Tumors with EGFR gene amplification frequently contain EGFR gene rearrangements, with the most common extracellular domain mutation being EGFRvIII. This mutation leads to a deletion of exons 2–7 of the EGFR gene and renders the mutant receptor incapable of binding any known ligand. Despite this, EGFRvIII displays low-level constitutive signaling that is augmented by reduced internalization and downregulation. Aberrant EGFRvIII signaling has been shown to be important in driving tumor progression and often correlates with poor prognosis. It is clear that EGFRvIII is expressed in a considerable proportion of patients with glioblastoma multiforme (GBM). The presence of EGFRvIII in other tumor types, however, remains controversial.
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4.2 ★★★★★
Based on 27 reviews
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Product Reviews
★★★★★ 5
GOOD INGREDIENTS FLUORIDE FREE YAAAY!!!
Color: Cinnamon Mint (Pack of 1)
I am very excited about this I hope it helps my grandson's teeth You know time will tell but it's a nice size and I'm just very grateful Thank you so much It's got some really nice ingredients in it that are unique and not in other toothpaste on top of the fact that it's fluoride free which there's no possible way I would consume any fluoride or allow my grandsons to do so if it has anything to do with me greatest blessings upon you
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Reviewed in the United States on May 16, 2026
★★★★★ 5
Best I’ve used in 40yrs
Color: A - Magic Mint (Pack of 1)
Fast shipping
Quality product
Great results
No after taste
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Reviewed in the United States on May 31, 2026
★★★★★ 5
Very pleasant nano hydroxyapatite toothpaste.
Color: A - Magic Mint (Pack of 3)
Bought this new nano hydroxyapatite toothpaste free of fluoride. This is a new technology toothpaste that reinforces enamel. The Mint taste is very pleasant.
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Reviewed in the United States on May 20, 2026
★★★★★ 4
Pineapple and papaya
Color: A - Magic Mint (Pack of 3), Color: A - Magic Mint (Pack of 3)
I like it okay. I will use all of it but I am unsure if I will buy it again. It foams very little. I feel like I use more than I do with other pastes/gels. My mouth feels clean without having that too minty/medicinal taste from traditional flouride pastes. It comes out of the tube easy and sticks to my brush. I didn’t know until after I purchased it that there is papaya and pineapple extracts. There IS a photo in the product description that says this and I neglected to click through them all. I have two members in my household that are allergic to those ingredients so I have not had them try it. The only taste is a mild mint though. I think the whitening effects of nanohydroxyapatite pastes is much better than other popular brands that boast “whitening.” My teeth simply look whiter and shiny.
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Reviewed in the United States on September 22, 2025
★★★★★ 5
GREAT CHOICE !!!
Color: A - Magic Mint (Pack of 1)
Definitely works as discribed helped with tooth sensitivity active ingredients help whiten and strengthen tooth enamel. I alternate 3 X a week woth normal Fluoride toothpastes and use this 2X a week. Total game changer
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Reviewed in the United States on May 21, 2026