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Description
FTH1 Recombinant Rabbit mAb (S-1372-136)Product Specification Host Rabbit Antigen FTH1 Synonyms Ferritin heavy chain; Ferritin H subunit; Cell proliferation inducing gene 15 protein; FTH; FTHL6 Immunogen Synthetic Peptide Location Cytoplasm, Lysosome Accession P02794 Clone Number S 1372 136 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu Positive Sample MCF7, HeLa, HT 29, Jurkat, HepG2 Purification Protein A Concentration 0. 5 mg ml Conjugation
Product Specification
| Host | Rabbit |
| Antigen | FTH1 |
| Synonyms | Ferritin heavy chain; Ferritin H subunit; Cell proliferation-inducing gene 15 protein; FTH; FTHL6 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Lysosome |
| Accession | P02794 |
| Clone Number | S-1372-136 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu |
| Positive Sample | MCF7, HeLa, HT-29, Jurkat, HepG2 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| IHC-P | 1:1000 | Hu |
| ICC | 1:500 | Hu |
Background
FTH1, also known as Ferritin Heavy Chain 1, is a protein-coding gene that plays a crucial role in iron metabolism. It encodes a subunit of ferritin, the major intracellular iron storage protein in both prokaryotic and eukaryotic organisms. The ferritin protein is composed of 24 subunits of heavy and light chains, with FTH1 being the heavy chain component. This protein helps catalyze the oxidation of Fe²⁺ to Fe³⁺, facilitating iron storage in a soluble and non-toxic form. Additionally, FTH1 possesses ferrous iron binding activity and is involved in various biological processes, including immune response, cell proliferation, and protection against oxidative stress. Defects in the FTH1 gene are associated with several diseases, such as neurodegenerative disorders and iron overload conditions like Hemochromatosis Type 5.
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