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Description
Occludin Recombinant Rabbit mAb (SDT-4588)Product Specification Host Rabbit Antigen Occludin Synonyms OCLN Location Cell membrane Accession Q16625 Clone Number SDT 4588 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Rt Positive Sample Caco 2, HepG2, A431, A549, HT 29, bEnd. 3, mouse colon, mouse small intestine, mouse liver, mouse kidney, mouse brain, mouse lung, rat colon, rat liver, rat kidney, rat brain, rat lung Predicted Reactivity Dg Purification
Product Specification
| Host | Rabbit |
| Antigen | Occludin |
| Synonyms | OCLN |
| Location | Cell membrane |
| Accession | Q16625 |
| Clone Number | SDT-4588 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | Caco-2, HepG2, A431, A549, HT-29, bEnd.3, mouse colon, mouse small intestine, mouse liver, mouse kidney, mouse brain, mouse lung, rat colon, rat liver, rat kidney, rat brain, rat lung |
| Predicted Reactivity | Dg |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
| IHC-P | 1:500 | Hu, Ms, Rt |
| ICC | 1:100 | Hu |
Background
Occludin is a approximately 65 kDa four-pass transmembrane protein, identified and named in 1993 as a pivotal component of tight junctions (TJs), primarily localized at the apical lateral membranes of epithelial and endothelial cells; featuring two extracellular loops, one intracellular loop, and a long C-terminal cytoplasmic tail, its extracellular loops mediate "zipper-like" sealing between adjacent cells via homo- or heterophilic interactions, thereby establishing a selective permeability barrier that strictly regulates paracellular transport and maintains cell polarity, while its C-terminus anchors tight junctions to the actin cytoskeleton by binding to cytoplasmic scaffolding proteins such as ZO-1, subsequently participating in the fine-tuned regulation of cell signaling, gene expression, proliferation, and differentiation, playing an indispensable central role in the construction of the blood-brain barrier, maintenance of tissue homeostasis, and pathological processes including inflammation and tumor metastasis.
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