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Description
FITC Mouse Anti-Human CD68 Antibody (S-R657)Product Specification Host Mouse Antigen CD68 Synonyms Macrosialin; Gp110 Location Lysosome, Endosome, Cell membrane Accession P34810 Clone Number S R657 Antibody Type Mouse mAb Isotype IgG2b,k Application ICFCM Reactivity Hu Positive Sample Human PBMC Purification Protein A Concentration 0. 05mg ml Conjugation FITC Physical Appearance Liquid Storage Buffer PBS, 25% Glycerol, 1% BSA, 0. 3% Proclin 300 Stability & Storage 12 months from date of receipt
Product Specification
| Host | Mouse |
| Antigen | CD68 |
| Synonyms | Macrosialin; Gp110 |
| Location | Lysosome, Endosome, Cell membrane |
| Accession | P34810 |
| Clone Number | S-R657 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2b,k |
| Application | ICFCM |
| Reactivity | Hu |
| Positive Sample | Human PBMC |
| Purification | Protein A |
| Concentration | 0.05mg/ml |
| Conjugation | FITC |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| ICFCM | 5μl per million cells in 100μl volume | Hu |
Background
CD68 is a highly glycosylated type I transmembrane glycoprotein predominantly expressed in cells of the monocyte-macrophage lineage, such as macrophages, microglia, and monocytes. It is also known as macrosialin in mice. This protein is mainly localized within the endosomal/lysosomal compartments of these cells and serves as a reliable marker for them. CD68 plays a crucial role in various immune processes, including phagocytosis, antigen presentation, and the regulation of immune responses. It is involved in the clearance of cellular debris, foreign substances, microbes, and even cancer cells. In different tissues, CD68-positive cells perform diverse functions. For example, in the liver, CD68 is expressed in Kupffer cells that filter blood and remove pathogens; in the lungs, alveolar macrophages with high CD68 levels maintain pulmonary homeostasis. Additionally, CD68 is notable in the central nervous system, where microglia express this marker to maintain neural health by clearing debris and modulating inflammatory responses.
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