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Description
CD72 Fc Chimera Protein, HumanProduct Specification Species Human Synonyms CD72, LYB2, CD72b, Lyb2 Accession P21854 Amino Acid Sequence Arg117 Asp359, with C terminal human IgG1 Fc
Product Specification
| Species | Human |
| Synonyms | CD72, LYB2, CD72b, Lyb2 |
| Accession | P21854 |
| Amino Acid Sequence | Arg117-Asp359, with C-terminal human IgG1 Fc RYLQVSQQLQQTNRVLEVTNSSLRQQLRLKITQLGQSAEDLQGSRRELAQSQEALQVEQRAHQAAEGQLQACQADRQKTKETLQSEEQQRRALEQKLSNMENRLKPFFTCGSADTCCPSGWIMHQKSCFYISLTSKNWQESQKQCETLSSKLATFSEIYPQSHSYYFLNSLLPNGGSGNSYWTGLSSNKDWKLTDDTQRTRTYAQSSKCNKVHKTWSWWTLESESCRSSLPYICEMTAFRFPDIEGRMDPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK |
| Expression System | HEK293 |
| Molecular Weight | 59-68kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | Human Fc Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference |
1、Wu H J. et al. (2009) CD72, a coreceptor with both positive and negative effects on B lymphocyte development and function. J Clin Immunol. 29: 12-21. 2、Adachi T. et al. (1998) The B cell surface protein CD72 recruits the tyrosine phosphatase SHP-1 upon tyrosine phosphorylation. J Immunol. 160: 4662-4665. 3、Adachi T. et al. (2000) CD72 negatively regulates signaling through the antigen receptor of B cells. J Immunol. 164: 1223-1229. |
Background
CD72 is a coreceptor of B cell receptor (BCR), which is expressed on all B cells starting at the pre-B cell stage, but its expression decreases significantly during differentiation into plasma cells. CD72 is a transmembrane receptor that is expressed as a homodimer. It has a conserved intracellular domain, which contains an immunoreceptor tyrosine-based inhibitory motif (ITIM) that binds SHP-1, a tyrosine phosphatase, and an ITIM-like motif that binds Grb2, an adaptor protein required to activate the Ras pathway. CD72 is known to play an important role in various B cell processes, including proliferation, apoptosis and differentiation. Mouse CD72 negatively regulates BCR signaling by recruiting Src homology 2 domain-containing protein tyrosine phosphatase-1 (SHP-1) at ITIM.
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4.4 ★★★★★
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Product Reviews
★★★★★ 5
Strong and durable
My everyday plates..cheap enough and strong enough ..buy all the time for microwaving and leftovers..they are strong enough to keep for a second round at the table
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Reviewed in the United States on May 15, 2026
★★★★★ 5
Good price
Size: 200 Count (Pack of 1)
Great quality
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Reviewed in the United States on May 26, 2026
★★★★★ 5
Best paper plates I've bought in years. I hope Amazon sticks with this supplier!.
Size: 200 Count (Pack of 1)
These paper plates were marked South Korea. They are strong, that don't stick together, the price is right. Love them, just hope the same kind are delivered with this order! We'll find out soon.
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Reviewed in the United States on March 29, 2026
★★★★★ 5
Uncoated
Size: 200 Count (Pack of 1)
One of the few offering low cost plates without coatings, often plastic
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Reviewed in the United States on March 20, 2026
★★★★★ 4
Very lightweight but good everyday
Size: 500 Count (Pack of 1)
These are great for everyday use. I use them under bowls when I microwave, to collect pieces of food that I’m going to throw away while I’m cooking. Good enough for toast or a microwaved muffin. They are lightweight and not meant for heavy amounts of food.
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Reviewed in the United States on May 14, 2026