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Description
MUC18/CD146 His Tag Protein, MouseProduct Specification Species Mouse Synonyms MUC18, CD146, METCAM, MCAM, Gicerin Accession Q8R2Y2 Amino Acid Sequence Val24 Val563, with C terminal 10*His
Product Specification
| Species | Mouse |
| Synonyms | MUC18, CD146, METCAM, MCAM, Gicerin |
| Accession | Q8R2Y2 |
| Amino Acid Sequence | Val24-Val563, with C-terminal 10*His VPGEEKQPVPTPDLVEAEVGSTALLKCGPSRASGNFSQVDWFLIHKERQILIFRVHQGKGQREPGEYEHRLSLQDSVATLALSHVTPHDERMFLCKSKRPRLQDHYVELQVFKAPEEPTIQANVVGIHVDRQELREVATCVGRNGYPIPQVLWYKNSLPLQEEENRVHIQSSQIVESSGLYTLKSVLSARLVKEDKDAQFYCELSYRLPSGNHMKESKEVTVPVFYPAEKVWVEVEPVGLLKEGDHVTIRCLTDGNPQPHFTINKKDPSTGEMEEESTDENGLLSLEPAEKHHSGLYQCQSLDLETTITLSSDPLELLVNYVSDVQVNPTAPEVQEGESLTLTCEAESNQDLEFEWLRDKTGQLLGKGPVLQLNNVRREAGGRYLCMASVPRVPGLNRTQLVSVGIFGSPWMALKERKVWVQENAVLNLSCEASGHPQPTISWNVNGSATEWNPDPQTVVSTLNVLVTPELLETGAECTASNSLGSNTTTIVLKLVTLTTLIPDSSQTTGLSTLTVSPHTRANSTSTEKKLPQPESKGVVGGGSGGGSHHHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | 80-100kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1、Hemi X. et al. (2020) CD146/sCD146 in the Pathogenesis and Monitoring of Angiogenic and Inflammatory Diseases. Biomedicines. 8(12): 592. |
Background
CD146 is a cell adhesion molecule expressed on endothelial cells, as well as on other cells such as mesenchymal stem cells and Th17 lymphocytes. This protein also exists in a soluble form, whereby it can be detected in biological fluids, including the serum or the cerebrospinal fluid (CSF). Some studies have highlighted the significance of CD146 and its soluble form in angiogenesis and inflammation, having been shown to contribute to the pathogenesis of many inflammatory autoimmune diseases, such as systemic sclerosis, mellitus diabetes, rheumatoid arthritis, inflammatory bowel diseases, and multiple sclerosis.
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4.3 ★★★★★
Based on 19 reviews
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Product Reviews
★★★★★ 5
Aesthetic Distribution Tool
This distribution tool is so aesthetically pleasing. It looks great on my tamp mat that sits out on my counter. The tool does have a more delicate feel but that was not unexpected since it is basically a bunch of grouped needles. I’ve not had any of my needles break or need replaced yet (I’ve only had my tool for about two weeks now though) but there are backup needles included with the tool so I am not worried about it!
This tool is super easy to use, you just stir it gently in your grounds to fluff them. Quality tools are going to cost a bit more so I feel like the price wasn’t unreasonable.
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Reviewed in the United States on May 21, 2026
★★★★★ 5
Hefty Feel
This is a solid feeling WDT tool. It has a good weight in the hand. While it may not have the fancy push down and auto rotating mechanism, it still functions very well. The stainless steel needles are long and can easily reach the bottom of the portafilter with a magnetic dosing funnel attached.
It's a solid WDT tool for the price. Easy to clean, easy to use, looks and feel premium.
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Reviewed in the United States on June 7, 2026
★★★★★ 5
Does a great job!
I gave it as part of a gift to my son and he loves it. It’s used every week and does a great job.
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Reviewed in the United States on May 24, 2026
★★★★★ 4
It’s fine.
I would prefer the needles be straight, and I couldn’t make them that way. The method for replacing the needles is … fine. I would also prefer the base of the holder be closed rather than open. It works well, but didn’t meet my expectations.
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Reviewed in the United States on April 14, 2026
★★★★★ 5
Elegant! 👍👍
I didnt just want a WDT tool. They basically all do the same job. I wanted something that was elegant and beautiful to look at. This is it!
No plastic here. The base is solid metal and thick heavy at the bottom so as to not get knocked over. Top is a real nice smooth wood.
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Reviewed in the United States on April 9, 2026
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