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Description
S-RMab® MUC1/EMA Recombinant Rabbit mAb,PBS Only (SDT-776-49)Product Specification Host Rabbit Antigen MUC1 Synonyms Mucin 1, MUC 1, CD227, CA 15 3, Breast carcinoma associated antigen DF3, Carcinoma associated mucin, Episialin, KL 6, PEMT, PUM, PEM, EMA, Tumor associated mucin Immunogen Synthetic Peptide Location Cytoplasm, Secreted, Cell membrane Accession P15941 Clone Number SDT 776 49 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC, IP, IF, ICFCM Reactivity Hu Purification Protein A
Product Specification
| Host | Rabbit |
| Antigen | MUC1 |
| Synonyms | Mucin-1, MUC-1, CD227, CA 15-3, Breast carcinoma-associated antigen DF3, Carcinoma-associated mucin, Episialin, KL-6, PEMT, PUM, PEM, EMA, Tumor-associated mucin |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Secreted, Cell membrane |
| Accession | P15941 |
| Clone Number | SDT-776-49 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC, IP, IF, ICFCM |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS |
| Stability & Storage | 12 months from date of receipt / reconstitution, 4 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:500 | |
| IHC-P | 1:1000 | |
| IP | 1:25 | |
| ICFCM | 1:250 | |
| ICC | 1:125 | |
| IF | 1:125 |
Background
MUC1 is a transmembrane protein normally expressed in glandular or luminal epithelial cells and hematopoietic cells and absent in skin epithelium and mesenchymal cells. Apical surface of almost all glandular and ductal epithelial cells, including respiratory, gastrointestinal, urogenital, hepatobiliary tracts, sebaceous and salivary glands. MUC1 is expressed in the central cells of pancreatic acini, intercalary duct epithelium, and interlobular duct epithelium, but not in the acinar epithelium, main pancreatic duct epithelium, and pancreatic islet epithelium. Overexpression is common in malignancies and leads to tumorigenesis. Increased expression is associated with poor prognosis of most carcinomas, including those involving breast, cervical, pancreatic, colorectal.
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