Pay in installments of $11.25 with
,
and
Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Aug 27 - Sep 1
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
TLR4 Recombinant Mouse mAb (SDT-3305)Product Specification Host Mouse Antigen TLR4 Synonyms Toll like receptor 4; CD284; Lps; Tlr4 Location Endosome, Cell membrane Accession Q9QUK6 Clone Number SDT 3305 Antibody Type Mouse mAb Isotype IgG2b,k Application IHC P Reactivity Hu, Ms, Rt Predicted Reactivity Pig Purification Protein A Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin 300 Stability & Storage 12
Product Specification
| Host | Mouse |
| Antigen | TLR4 |
| Synonyms | Toll-like receptor 4; CD284; Lps; Tlr4 |
| Location | Endosome, Cell membrane |
| Accession | Q9QUK6 |
| Clone Number | SDT-3305 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2b,k |
| Application | IHC-P |
| Reactivity | Hu, Ms, Rt |
| Predicted Reactivity | Pig |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| IHC-P | 1:250 | Hu |
Background
Toll-like receptor 4 (TLR4) is a type I transmembrane pattern-recognition receptor expressed predominantly on macrophages, dendritic cells, and epithelial barriers; upon recognition of lipopolysaccharide from Gram-negative bacteria in complex with MD-2 and CD14, it homodimerizes and initiates a MyD88- and TRIF-dependent signaling cascade that activates NF-κB, MAPKs, and IRF3, driving the transcription of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6), type I interferons, and co-stimulatory molecules essential for innate immunity and the subsequent shaping of adaptive responses, while excessive or dysregulated TLR4 activation contributes to septic shock, chronic inflammatory disorders such as atherosclerosis and metabolic syndrome, and ischemia–reperfusion injury, making it a therapeutic target for antagonists like lipid A analogs and monoclonal antibodies.
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy