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Description
CYP3A4 Recombinant Rabbit mAb (S-2281-2)Product Specification Host Rabbit Antigen CYP3A4 Synonyms Cytochrome P450 3A4; 1,4 cineole 2 exo monooxygenase; 1,8 cineole 2 exo monooxygenase; Albendazole monooxygenase (sulfoxide forming); Albendazole sulfoxidase; CYPIIIA3; CYP3A3 Immunogen Synthetic Peptide Location Endoplasmic reticulum Accession P08684 Clone Number S 2281 2 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Ms Positive Sample mouse liver Purification Protein A
Product Specification
| Host | Rabbit |
| Antigen | CYP3A4 |
| Synonyms | Cytochrome P450 3A4; 1,4-cineole 2-exo-monooxygenase; 1,8-cineole 2-exo-monooxygenase; Albendazole monooxygenase (sulfoxide-forming); Albendazole sulfoxidase; CYPIIIA3; CYP3A3 |
| Immunogen | Synthetic Peptide |
| Location | Endoplasmic reticulum |
| Accession | P08684 |
| Clone Number | S-2281-2 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Ms |
| Positive Sample | mouse liver |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:2000 | Ms |
Background
CYP3A4 is a 57-kDa cytochrome P450 mono-oxygenase anchored in the endoplasmic reticulum of human liver and intestine, where its large, highly lipophilic active site binds a broad spectrum of substrates—including more than half of all marketed drugs—catalyzing the insertion of an oxygen atom into C–H or C=C bonds to increase polarity and facilitate elimination; expression is up-regulated by nuclear receptor PXR and down-regulated by inflammatory cytokines, leading to up to 40-fold inter-individual variability, and common genetic variants (e.g., *22) modestly alter activity, while potent inhibitors like ketoconazole or grapefruit furanocoumarins and inducers like rifampicin or St. John’s wort can precipitate clinical drug–drug interactions, making CYP3A4 a central determinant of systemic exposure, efficacy, and toxicity for statins, calcium-channel blockers, immunosuppressants, and many oncology agents.
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