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Description
B7-H4 Recombinant Rabbit mAb (SDT-314-447-2)Product Specification Host Rabbit Antigen B7 H4 Synonyms V set domain containing T cell activation inhibitor 1, B7 homolog 4, B7h. 5, Protein B7S1, T cell costimulatory molecule B7x, VTCN1 Immunogen Recombinant Protein Location Cell membrane Accession Q7Z7D3 Clone Number SDT 314 447 2 Antibody Type Recombinant mAb Application WB, IHC P, ICC, IP Reactivity Hu Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance
Product Specification
| Host | Rabbit |
| Antigen | B7-H4 |
| Synonyms | V-set domain-containing T-cell activation inhibitor 1, B7 homolog 4, B7h.5, Protein B7S1, T-cell costimulatory molecule B7x, VTCN1 |
| Immunogen | Recombinant Protein |
| Location | Cell membrane |
| Accession | Q7Z7D3 |
| Clone Number | SDT-314-447-2 |
| Antibody Type | Recombinant mAb |
| Application | WB, IHC-P, ICC, IP |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:200 | null |
| IP | 1:50 | null |
| IHC | 1:400 | null |
| ICC | 1:50 | null |
Background
B7-H4 is a transmembrane protein that binds an unknown receptor on activated T cells resulting in inhibition of T-cell effector function via cell cycle arrest, decreased proliferation, and reduced IL-2 production. B7-H4 is up-regulated on the surface of cancer cells and immunosuppressive tumor-associated macrophages (TAMs) in a variety of human cancers. Notably, B7-H4 expression levels inversely correlate with patient survival in ovarian cancer, cholangiocarcinoma, breast cancer and endometrial cancer, making B7-H4 an attractive candidate for therapeutic intervention.
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