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Description
Rat Anti-Mouse TNF α Antibody (S-R604)Product Specification Host Rat Antigen TNF alpha Synonyms Tumor necrosis factor; Cachectin; TNF alpha; Tumor necrosis factor ligand superfamily member 2 (TNF a); Tnfa; Tnfsf2; Tnf Location Secreted, Cell membrane Accession P06804 Clone Number S R604 Antibody Type Rat mAb Isotype IgG1,k Application ICFCM Reactivity Ms Purification Protein G Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7. 4 Stability &
Product Specification
| Host | Rat |
| Antigen | TNF alpha |
| Synonyms | Tumor necrosis factor; Cachectin; TNF-alpha; Tumor necrosis factor ligand superfamily member 2 (TNF-a); Tnfa; Tnfsf2; Tnf |
| Location | Secreted, Cell membrane |
| Accession | P06804 |
| Clone Number | S-R604 |
| Antibody Type | Rat mAb |
| Isotype | IgG1,k |
| Application | ICFCM |
| Reactivity | Ms |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| ICFCM | 1:2000 | Ms |
Background
Tumor necrosis factor alpha (TNF alpha) is a multifunctional cytokine that plays a crucial role in regulating immune responses and inflammation. It is primarily produced by macrophages, but can also be synthesized by other cell types including monocytes, neutrophils, and T cells. TNF alpha exerts its effects by binding to two distinct receptors, TNF receptor 1 (TNFR1) and TNF receptor 2 (TNFR2), which are widely expressed on various cell types. It is involved in a wide range of biological processes such as promoting inflammation, inducing apoptosis, and stimulating cell proliferation and differentiation. In the context of immune response, TNF alpha helps to activate immune cells and enhance their ability to combat infections and cancer cells. However, excessive or uncontrolled production of TNF alpha can lead to chronic inflammatory diseases like rheumatoid arthritis, inflammatory bowel disease, and psoriasis. Therefore, TNF alpha is a key target for therapeutic interventions aimed at modulating the immune system and treating inflammatory disorders.
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