SKU: 88595654252

Ku80 Recombinant Rabbit mAb (S-R226)

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Description

Ku80 Recombinant Rabbit mAb (S-R226)Product Specification Host Rabbit Antigen Ku80 Synonyms X ray repair cross complementing protein 5, 86 kDa subunit of Ku antigen, ATP dependent DNA helicase 2 subunit 2, ATP dependent DNA helicase II 80 kDa subunit, CTC85, CTCBF, XRCC5, Ku86, Lupus Ku autoantigen protein p86, Nuclear factor IV, Thyroid lupus autoantigen (TLAA) Location Nucleus, Nucleolus Accession P13010 Clone Number S R226 Antibody Type Recombinant mAb Application WB, IHC P, ICC,

Product Specification


Host Rabbit
Antigen Ku80
Synonyms X-ray repair cross-complementing protein 5, 86 kDa subunit of Ku antigen, ATP-dependent DNA helicase 2 subunit 2, ATP-dependent DNA helicase II 80 kDa subunit, CTC85, CTCBF, XRCC5, Ku86, Lupus Ku autoantigen protein p86, Nuclear factor IV, Thyroid-lupus autoantigen (TLAA)
Location Nucleus, Nucleolus
Accession P13010
Clone Number S-R226
Antibody Type Recombinant mAb
Application WB, IHC-P, ICC, ICFCM, IP
Reactivity Hu
Purification Protein A
Concentration 0.5 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300
Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
WB 1:1000 null
IHC 1:500 null
ICFCM 1:500 null
ICC 1:500 null
IP 1:50 null

Background

Ku80 is a protein that, in humans, is encoded by the XRCC5 gene. Together, Ku70 and Ku80 make up the Ku heterodimer, which binds to DNA double-strand break ends and is required for the non-homologous end joining (NHEJ) pathway of DNA repair. It is also required for V(D)J recombination, which utilizes the NHEJ pathway to promote antigen diversity in the mammalian immune system. In addition to its role in NHEJ, Ku is required for telomere length maintenance and subtelomeric gene silencing. Ku80 protein expression was found to be deficient in melanoma. In addition, low expression of Ku80 was found in 15% of adenocarcinoma type and 32% of squamous cell type non-small cell lung cancers, and this was correlated with hypermethylation of the XRCC5 promoter.

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SKU: 88595654252

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4.3 ★★★★★
Based on 14 reviews
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Copper Fox
Whiting, US
★★★★★ 4
Close...but not quite the length.
Size: XL (16 in), Style: 2 Knot Rope Bone, Size: XL (16 in), Style: 2 Knot Rope Bone
I will admit, I thought their picture was off, because when I saw 16" in the title I was expecting the distance between the knots to be 16 inches in length. So if you're looking for a good length tug-of-war rope for a medium to large dog, look somewhere else. I'm not returning it, it's good quality cotton rope asides that. My dog needs a new toy and cotton ones are harder to find. Next time I'm going to their amazon store directly to look for what I wanted though. I will buy from them again, I like the quality and the fact that, for once, cotton is actually cotton.
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Reviewed in the United States on February 12, 2025
B
Verified Purchase
Brigette Ritchie
Lowell, US
★★★★★ 5
Great toy
Size: Small (9 in), Style: 2 Knot Rope Bone
I got this because my puppy chews through the other kinds of rope toys. This one is laying though. Only thing is, she's eating off the loose strings. Lol So she's pooping strings all the time
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Reviewed in the United States on February 14, 2026
J
Verified Purchase
Jeffrey T DeLapp
Omaha, US
★★★★★ 5
The strings on the end are super engaging and the rope itself holds up really well
Size: Small (9 in), Style: 2 Knot Rope Bone
Super cost effective way to redirect chewing!! Our 4 month old corgi quickly made this is favorite toy. He loves the strings on the side and tugs on it endlessly, and the main rope was pretty firm at first but has softened up while maintaining its strength. Highly recommend as an interactive toy or just something for your dog to chew on their own so you can take some time to chill on your own!
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Reviewed in the United States on July 25, 2024
J
Verified Purchase
Julie
Dallas, US
★★★★★ 3
Not for aggressive chewers!
Size: Large (14 in), Style: 2 Knot Rope Bone
At first glance, this rope toy seemed sturdy and well made. However, within an hour of my Vizsla chewing on it, she had already bitten off and unfortunately swallowed several of the fringes. The center of the rope also began to unravel. This toy may be suitable for smaller dogs or those that aren’t aggressive chewers, but I wouldn’t recommend it for large dogs or heavy chewers. Additionally, while it may measure 14 inches before being knotted at the ends, the total length is shorter than advertised.
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Reviewed in the United States on April 5, 2026
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Verified Purchase
BErickson
Lexington, US
★★★★★ 5
Two knots, Not 3…
Size: Large (14 in), Style: 2 Knot Rope Bone
Been subscribed & saving on 3 knot version for years. My dogs gnaw through the center knot and they quickly unravel. This 2 knot version seems to last much longer.
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Reviewed in the United States on October 19, 2025

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