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Description
MX1 Rabbit Polyclonal AntibodyProduct Specification Host Rabbit Antigen MX1 Synonyms Interferon induced GTP binding protein Mx1; Interferon induced protein p78 (IFI 78K); Interferon regulated resistance GTP binding protein MxA; Myxoma resistance protein 1; Myxovirus resistance protein 1 Immunogen Synthetic Peptide Location Cytoplasm, Nucleus, Endoplasmic reticulum Accession P20591 Antibody Type Polyclonal antibody Isotype IgG Application WB, IHC P, ICC Reactivity Hu Purification
Product Specification
| Host | Rabbit |
| Antigen | MX1 |
| Synonyms | Interferon-induced GTP-binding protein Mx1; Interferon-induced protein p78 (IFI-78K); Interferon-regulated resistance GTP-binding protein MxA; Myxoma resistance protein 1; Myxovirus resistance protein 1 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus, Endoplasmic reticulum |
| Accession | P20591 |
| Antibody Type | Polyclonal antibody |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu |
| Purification | Immunogen Affinity |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| IHC-P | 1:1000 | Hu |
| ICC | 1:500 | Hu |
Background
MX1 (Myxovirus resistance protein 1) is an interferon-inducible dynamin-like large GTPase that constitutes a frontline intracellular defense against a broad spectrum of RNA and DNA viruses by recognizing viral nucleocapsids, oligomerizing into helical assemblies driven by GTP binding and hydrolysis, and sequestering or mis-sorting these capsids away from replication sites, thereby blocking viral transcription and genome amplification; the 662-aa human protein (also termed MxA) contains an N-terminal GTPase domain connected via a bundle-signalling element to a C-terminal stalk that together mediate self-assembly, while a disordered L4 loop and a unique N-terminal segment dictate its predominantly cytoplasmic localization, determine its extensive antiviral breadth including influenza A, vesicular stomatitis, bunyaviruses and HBV, and explain why polymorphisms or truncations in MX1 can abolish this activity and increase host susceptibility to infection.
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