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Description
Mouse Anti-Human CD56 Antibody (S-3499)Product Specification Host Mouse Antigen NCAM 1 CD56 Synonyms Neural cell adhesion molecule 1; N CAM 1; NCAM 1; NCAM; NCAM1 Location Secreted, Cell membrane Accession P13591 Clone Number S 3499 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Positive Sample Human PBMC Purification Protein G Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7. 4 Stability & Storage 12 months from date of
Product Specification
| Host | Mouse |
| Antigen | NCAM-1/CD56 |
| Synonyms | Neural cell adhesion molecule 1; N-CAM-1; NCAM-1; NCAM; NCAM1 |
| Location | Secreted, Cell membrane |
| Accession | P13591 |
| Clone Number | S-3499 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | Human PBMC |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1:400 | Hu |
Background
Neural cell adhesion molecule 1 (NCAM-1), also known as CD56, is a cell adhesion protein belonging to the immunoglobulin superfamily. It is expressed on various cell types including neurons, muscle cells, and immune cells like natural killer (NK) cells. NCAM-1/CD56 plays crucial roles in cell-to-cell and cell-matrix interactions during development and differentiation, regulating processes such as neurogenesis, neurite outgrowth, axonal guidance, and cell migration in the nervous system. In the immune system, it is involved in the expansion of T lymphocytes, B lymphocytes, and NK cells. NCAM-1/CD56 also triggers signaling cascades involving FYN-focal adhesion kinase (FAK), mitogen-activated protein kinase (MAPK), and phosphatidylinositol 3-kinase (PI3K). Additionally, it serves as a biomarker for certain diseases, such as malignant tumors in the nervous system and neuroendocrine carcinoma.
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