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Description
Collagen ll Recombinant Rabbit mAb (S-3360)Product Specification Host Rabbit Antigen Collagen II Synonyms Collagen alpha 1(II) chain; Alpha 1 type II collagen; COL2A1 Location Secreted Accession P02458 Clone Number S 3360 Antibody Type Recombinant mAb Isotype IgG Application IHC P Reactivity Hu, Rt Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin 300 Stability & Storage 12 months
Product Specification
| Host | Rabbit |
| Antigen | Collagen II |
| Synonyms | Collagen alpha-1(II) chain; Alpha-1 type II collagen; COL2A1 |
| Location | Secreted |
| Accession | P02458 |
| Clone Number | S-3360 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | IHC-P |
| Reactivity | Hu, Rt |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| IHC-P | 1:200 | Hu, Rt |
Background
Collagen II, also known as type II collagen, is a crucial fibrillar protein predominantly found in cartilaginous tissues, including hyaline cartilage and articular cartilage, where it constitutes up to 90% of the collagen content. It is synthesized by chondrocytes and is essential for maintaining the structural integrity and resilience of cartilage. Collagen II is formed by homotrimers of the collagen type II alpha-1 chain (α1(II)), and its molecular structure includes a central triple-helical domain flanked by N- and C-propeptides. This collagen is also present in the vitreous humor of the eye, intervertebral discs, and the inner ear. Mutations in the gene encoding Collagen II (COL2A1) are associated with various skeletal and connective tissue disorders, such as Stickler syndrome and Kniest dysplasia.
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