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Description
APC Mouse Anti-Human CD11b Antibody (S-R404)Product Specification Host Mouse Antigen CD11b Synonyms Integrin alpha M; CD11 antigen like family member B; CR 3 alpha chain; Cell surface glycoprotein MAC 1 subunit alpha; Leukocyte adhesion receptor MO1; Neutrophil adherence receptor; CR3A; ITGAM Location Cell membrane Accession P11215 Clone Number S R404 Antibody Type Mouse mAb Isotype IgG2b,k Application FCM Reactivity Hu Positive Sample Human peripheral blood Leukocytes Purification Protein A
Product Specification
| Host | Mouse |
| Antigen | CD11b |
| Synonyms | Integrin alpha-M; CD11 antigen-like family member B; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; Leukocyte adhesion receptor MO1; Neutrophil adherence receptor; CR3A; ITGAM |
| Location | Cell membrane |
| Accession | P11215 |
| Clone Number | S-R404 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2b,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | Human peripheral blood Leukocytes |
| Purification | Protein A |
| Concentration | 0.2 mg/ml |
| Conjugation | APC |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD11b, also known as integrin alpha M, is a transmembrane glycoprotein that pairs with CD18 to form the Mac-1 integrin, also referred to as complement receptor type 3 (CR3). It is predominantly expressed on the surface of myeloid cells, including monocytes, neutrophils, macrophages, and microglia. CD11b plays a crucial role in mediating cell adhesion and migration, facilitating the interaction between immune cells and their targets. It is involved in phagocytosis, the process by which cells engulf and eliminate foreign particles or debris. Additionally, CD11b acts as a receptor for complement C3bi, mediating complement-coated particle uptake, and it binds to various ligands such as intercellular adhesion molecules (ICAMs) and fibrinogen, contributing to cell-mediated cytotoxicity, chemotaxis, and immune cell activation.
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Exchange/Return Notes
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