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Description
UltraSensKine Human IL-1β ELISA KitProduct Specification Antigen IL 1 Immunogen Recombinant Protein Antibody Type Recombinant mAb Reactivity Human Purification Protein A Stability & Storage 12 months from date of receipt reconstitution, 2 to 8'C as supplied. Kit Precision Intra assay: 5. 0% Inter assay: 7. 0% Sample type Cell culture supernatant, SerumPlasma Assay type Sandwich(quantitative) Sensitivity 3. 884pg ml Range 15. 63pg mL 1000pg mL Recovery Cell culture supernatant: 85%
Product Specification
| Antigen | IL-1β |
| Immunogen | Recombinant Protein |
| Antibody Type | Recombinant mAb |
| Reactivity | Human |
| Purification | Protein A |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8'C as supplied. |
Kit
| Precision | Intra-assay: 5.0%； Inter-assay: 7.0% |
| Sample type | Cell culture supernatant, Serum，Plasma |
| Assay type | Sandwich(quantitative) |
| Sensitivity | 3.884pg/ml |
| Range | 15.63pg/mL – 1000pg/mL |
| Recovery | Cell culture supernatant: 85% Serum: 107% Plasma: 101% |
| Assay time | 2.5 hours |
| Species reactivity | Human |
Background
Interleukin-1 beta (IL-1β) also known as leukocytic pyrogen, leukocytic endogenous mediator, mononuclear cell factor, lymphocyte activating factor and other names, is a cytokine protein that in humans is encoded by the IL1βgene. IL-1β is a member of the interleukin 1 family of cytokines. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. Increased production of IL-1β causes a number of different autoinflammatory syndromes, most notably the monogenic conditions referred to as Cryopyrin-Associated Periodic Syndromes (CAPS), due to mutations in the inflammasome receptor NLRP3 which triggers processing of IL-1β.
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