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Description
PD-L1 Recombinant Rabbit mAb (SDT-R017)Product Specification Host Rabbit Antigen PD L1 Synonyms Programmed cell death 1 ligand 1, CD274, B7 H1 Immunogen N A Location Membrane Accession Q9NZQ7 Clone Number SDT R017 Antibody Type Rabbit mAb Application WB, IHC P, IF Reactivity Hu Purification Protein A Concentration 0. 5 mg ml Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin 300 Stability & Storage 12 months from date of receipt reconstitution, 20 C as
Product Specification
| Host | Rabbit |
| Antigen | PD-L1 |
| Synonyms | Programmed cell death 1 ligand 1, CD274, B7-H1 |
| Immunogen | N/A |
| Location | Membrane |
| Accession | Q9NZQ7 |
| Clone Number | SDT-R017 |
| Antibody Type | Rabbit mAb |
| Application | WB, IHC-P, IF |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| IHC-P | 1:500 | null |
| WB | 1:1000 | null |
| IF | 1:100 | null |
Background
Programmed death-ligand 1 (PD-L1) also known as cluster of differentiation 274 (CD274) or B7 homolog 1 (B7-H1) is a protein that in humans is encoded by the CD274 gene. Programmed death-ligand 1 (PD-L1) is a 40kDa type 1 transmembrane protein that has been speculated to play a major role in suppressing the adaptive arm of immune systems during particular events such as pregnancy, tissue allografts, autoimmune disease and other disease states such as hepatitis. The binding of PD-L1 to the inhibitory checkpoint molecule PD-1 transmits an inhibitory signal based on interaction with phosphatases (SHP-1 or SHP-2) via Immunoreceptor Tyrosine-Based Switch Motif (ITSM). This reduces the proliferation of antigen-specific T-cells in lymph nodes, while simultaneously reducing apoptosis in regulatory T cells (anti-inflammatory, suppressive T cells) - further mediated by a lower regulation of the gene Bcl-2. Upregulation of PD-L1 on immune cells (especially myeloid cells) can also lead to formation of an immunosuppressive environment in a highly localized manner that also allow the cancer cells to proliferate.
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4.5 ★★★★★
Based on 5 reviews
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Product Reviews
★★★★★ 5
Comprehensive, clear and coherent!
Format: Paperback
The iTEP Practice Guide combines a no-nonsense approach to the specific iTEP tests and at the same time offers exercises that task the student with what they need to know. Exercises not only serve the purpose of scoring well, but the overall approach is communicative competence. We use the text in our group and one-to-one classes with very positive--and lasting--results.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on July 23, 2019
★★★★★ 1
No recomiendo
Format: Paperback
Muy malo, no vine completo, además se demoró mucho más de lo que decía al momento de comprarlo. Solo aplazaban la fecha de entrega sin consultar cómo afectaba al cliente. Yo tuve que presentar el examen sin el libro, porque no llegó en la fecha que decía al comprarlo y después se cambió 3 veces la fecha, casi cumpliendo el mes.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on December 30, 2025
★★★★★ 5
Brings a Smile to your face
In this book you will discover why Lisa is not only awesome. But probably why she's not that popular. You'll figure out what she loves and hates. A chilling tale of her and nurse Milhouse. Why her fellow students and friends find her annoying. Get to see what an average day of hers is like, and much more.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 30, 2013
★★★★★ 5
thanks
thank you for the fast delivery I love the Simpsons!!! they are wonderfully funny and I love the fact's in the book and the little notes in it that are funny things you may not have known!!
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Reviewed in the United States on September 24, 2013
★★★★★ 5
It is a great book
This book is a great book. It is funny with a mini comic and mini story and has fun parts with different Simpsons characters
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on January 12, 2014
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