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Description
PGC1 beta Recombinant Rabbit mAb (S-1212-146)Product Specification Host Rabbit Antigen PGC1 beta Synonyms Peroxisome proliferator activated receptor gamma coactivator 1 beta; PGC 1 beta; PPAR gamma coactivator 1 beta; PPARGC 1 beta; PGC 1 related estrogen receptor alpha coactivator; PERC; PGC1; PGC1B; PPARGC1; PPARGC1B Immunogen Synthetic Peptide Location Nucleus Accession Q86YN6 Clone Number S 1212 146 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu Positive
Product Specification
| Host | Rabbit |
| Antigen | PGC1 beta |
| Synonyms | Peroxisome proliferator-activated receptor gamma coactivator 1-beta; PGC-1-beta; PPAR-gamma coactivator 1-beta; PPARGC-1-beta; PGC-1-related estrogen receptor alpha coactivator; PERC; PGC1; PGC1B; PPARGC1; PPARGC1B |
| Immunogen | Synthetic Peptide |
| Location | Nucleus |
| Accession | Q86YN6 |
| Clone Number | S-1212-146 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu |
| Positive Sample | MCF7, HeLa, SH-SY5Y |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| IHC-P | 1:1000 | Hu |
| ICC | 1:500 | Hu |
Background
PGC-1β (Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1 beta) is a transcriptional coactivator that plays a crucial role in regulating cellular energy metabolism, mitochondrial biogenesis, and lipid homeostasis. It shares significant functional overlap with its more extensively studied counterpart, PGC-1α, but has distinct roles in specific tissues. PGC-1β is involved in enhancing oxidative phosphorylation (OXPHOS) and fatty acid oxidation (FAO) in mitochondria, thereby supporting cellular energy production. In diseases such as cancer, PGC-1β can have dual effects; for instance, in colorectal cancer, it acts as a downstream effector of oncogenic pathways, promoting cell survival and tumor growth. In hepatocellular carcinoma, PGC-1β can both support tumor anabolism by regulating lipid synthesis and contribute to drug resistance through mitochondrial adaptations. Its complex interactions with various transcription factors and metabolic pathways highlight its importance in both physiological and pathological contexts.
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