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Description
EGFR Rabbit Polyclonal AntibodyProduct Specification Host Rabbit Antigen EGFR Synonyms Epidermal growth factor receptor; Proto oncogene c ErbB 1; Receptor tyrosine protein kinase erbB 1; ERBB; ERBB1; HER1; EGF Receptor Immunogen Synthetic Peptide Location Nucleus, Secreted, Endosome, Cell membrane, Endoplasmic reticulum Accession P00533 Antibody Type Polyclonal antibody Isotype IgG Application WB Reactivity Hu Positive Sample A431 Predicted Reactivity Mq Purification Immunogen
Product Specification
| Host | Rabbit |
| Antigen | EGFR |
| Synonyms | Epidermal growth factor receptor; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1; ERBB; ERBB1; HER1; EGF Receptor |
| Immunogen | Synthetic Peptide |
| Location | Nucleus, Secreted, Endosome, Cell membrane, Endoplasmic reticulum |
| Accession | P00533 |
| Antibody Type | Polyclonal antibody |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu |
| Positive Sample | A431 |
| Predicted Reactivity | Mq |
| Purification | Immunogen Affinity |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
Background
The EGFR (Epidermal Growth Factor Receptor) is a transmembrane glycoprotein located on the cell membrane and belongs to the ErbB receptor tyrosine kinase family (HER1/ErbB1). Its structure consists of three main domains: an extracellular region, a transmembrane region, and an intracellular region. The extracellular region contains four domains (I-IV), with domains II and IV being cysteine-rich and responsible for binding ligands (such as EGF and TGF-α), leading to receptor dimerization. The transmembrane region is a single α-helix that anchors the receptor in the cell membrane. The intracellular region possesses tyrosine kinase activity and includes a juxtamembrane domain, a kinase domain (with an ATP-binding site), and a C-terminal regulatory tail containing multiple autophosphorylation sites (e.g., Y992, Y1045, Y1068). EGFR activates downstream signaling pathways such as RAS/RAF/MEK/ERK and PI3K/AKT, regulating cell proliferation, differentiation, migration, and survival. Mutations or overexpression of EGFR are strongly associated with various cancers, including lung and colorectal cancers, making it a key target for drugs like gefitinib and osimertinib.
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