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Description
LIN28B Recombinant Rabbit mAb (S-2360-117)Product Specification Host Rabbit Antigen LIN28B Synonyms Protein lin 28 homolog B; Lin 28B; CSDD2 Immunogen Recombinant Protein Location Cytoplasm, Nucleus Accession Q6ZN17 Clone Number S 2360 117 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu Positive Sample HepG2, K562, HEK 293, JAR Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40%
Product Specification
| Host | Rabbit |
| Antigen | LIN28B |
| Synonyms | Protein lin-28 homolog B; Lin-28B; CSDD2 |
| Immunogen | Recombinant Protein |
| Location | Cytoplasm, Nucleus |
| Accession | Q6ZN17 |
| Clone Number | S-2360-117 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu |
| Positive Sample | HepG2, K562, HEK-293, JAR |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:5000 | Hu |
| IHC-P | 1:1000 | Hu |
| ICC | 1:500 | Hu |
Background
LIN28B is an evolutionarily-conserved RNA-binding protein that acts as a potent developmental timing regulator and oncofetal factor by selectively binding and blocking the biogenesis of let-7 family microRNAs, thereby relieving repression of pluripotency, cell-cycle, and metabolic genes; it is predominantly expressed during embryogenesis and in many cancers, where its overexpression promotes self-renewal, metabolic reprogramming, and aggressive phenotypes through both let-7–dependent and independent mechanisms, including direct stabilization of IGF2, HMGA1, and MYC mRNAs and activation of the PI3K/AKT/mTOR and WNT/β-catenin pathways, making LIN28B a critical driver of oncogenesis, stemness, and resistance to therapy across diverse tumor types.
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