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Description
Transferrin Receptor 2/TFR2 Recombinant Rabbit mAb (S-1735-133)Product Specification Host Rabbit Antigen Transferrin Receptor 2 TFR2 Synonyms Transferrin receptor protein 2; TfR2 Immunogen Synthetic Peptide Location Cytoplasm, Cell membrane Accession Q9UP52 Clone Number S 1735 133 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu Positive Sample TF 1, HepG2, K562 Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40%
Product Specification
| Host | Rabbit |
| Antigen | Transferrin Receptor 2/TFR2 |
| Synonyms | Transferrin receptor protein 2; TfR2 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Cell membrane |
| Accession | Q9UP52 |
| Clone Number | S-1735-133 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu |
| Positive Sample | TF-1, HepG2, K562 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| IHC-P | 1:250 | Hu |
Background
Transferrin Receptor 2 (TFR2) is a single-pass type II membrane protein primarily expressed in the liver and bone marrow, playing a crucial role in iron homeostasis. Unlike its more widely studied counterpart, Transferrin Receptor 1 (TFR1), TFR2 is specifically involved in regulating iron uptake and signaling. It interacts with transferrin, a blood plasma protein that transports iron, and helps modulate the expression of hepcidin, the master regulator of iron absorption and distribution in the body. Mutations in the TFR2 gene are associated with hereditary hemochromatosis type III, a condition characterized by excessive iron accumulation. Additionally, TFR2 is involved in erythropoiesis, as it coordinates erythroid iron availability with erythropoietin receptor sensitivity. Its therapeutic potential lies in treating iron-related disorders, such as hereditary hemochromatosis and anemia of chronic disease, by modulating iron absorption and distribution.
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