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Description
Rat Anti-Mouse CD223 Antibody (S-R624)Product Specification Host Rat Antigen CD223 Synonyms Lymphocyte activation gene 3 protein; LAG 3; Activation induced cytidine deaminase linked autoimmunity protein (Aida); Lag3 Location Cell membrane Accession Q61790 Clone Number S R624 Antibody Type Rat mAb Isotype IgG1,k Application FCM Reactivity Ms Positive Sample C57BL 6 mouse splenocytes Purification Protein G Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage
Product Specification
| Host | Rat |
| Antigen | CD223 |
| Synonyms | Lymphocyte activation gene 3 protein; LAG-3; Activation-induced cytidine deaminase-linked autoimmunity protein (Aida); Lag3 |
| Location | Cell membrane |
| Accession | Q61790 |
| Clone Number | S-R624 |
| Antibody Type | Rat mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | C57BL/6 mouse splenocytes |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 1:2000 | Ms |
Background
CD223, also known as Lymphocyte Activation Gene-3 (LAG-3), is a type I transmembrane protein and a member of the immunoglobulin superfamily. It is an inhibitory immune checkpoint receptor that is selectively expressed on activated T cells, regulatory T cells, natural killer (NK) cells, and plasmacytoid dendritic cells. LAG-3 shares significant homology with CD4, particularly in its extracellular region, which contains four immunoglobulin-like domains. The molecule has a high-affinity binding to MHC class II molecules, which is its primary ligand, and this interaction negatively regulates T cell activation, proliferation, and cytokine production. Additionally, LAG-3 is involved in the negative regulation of regulatory T cell differentiation and the activation of plasmacytoid dendritic cells. In the context of cancer, LAG-3 is upregulated on tumor-infiltrating lymphocytes and is associated with tumor immune evasion, making it a promising target for cancer immunotherapy.
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