SKU: 94388879969

Myogenin Recombinant Rabbit mAb (SDT-3351)

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Description

Myogenin Recombinant Rabbit mAb (SDT-3351)Product Specification Host Rabbit Antigen Myogenin Synonyms Class C basic helix loop helix protein 3 (bHLHc3); Myogenic factor 4 (Myf 4); BHLHC3; MYF4; MYOG Location Nucleus Accession P15173 Clone Number SDT 3351 Antibody Type Recombinant mAb Isotype IgG Application IHC P Reactivity Hu Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin 300

Product Specification


Host Rabbit
Antigen Myogenin
Synonyms Class C basic helix-loop-helix protein 3 (bHLHc3); Myogenic factor 4 (Myf-4); BHLHC3; MYF4; MYOG
Location Nucleus
Accession P15173
Clone Number SDT-3351
Antibody Type Recombinant mAb
Isotype IgG
Application IHC-P
Reactivity Hu
Purification Protein A
Concentration 0.5 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
IHC-P 1:250 Hu

Background

Myogenin is a basic helix-loop-helix transcription factor encoded by the MYOG gene that serves as the master regulator of skeletal muscle differentiation, binding to E-box motifs in promoters of muscle-specific genes like desmin, myosin heavy chain, and the acetylcholine receptor to orchestrate terminal differentiation and fusion of myoblasts into multinucleated myotubes; its expression is induced by the upstream myogenic regulatory factors MyoD and Myf5, and its activity is modulated by interactions with E proteins, p300/CBP coactivators, and MEF2 family members, while in pathophysiology MYOG mutations or altered expression are linked to congenital myopathies and its ectopic expression in tumors is exploited as a sensitive immunohistochemical marker for rhabdomyosarcoma.

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SKU: 94388879969

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