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Description
Prolactin R/PRLR His Tag Protein, HumanProduct Specification Species Human Synonyms Prolactin R, PRLR, PRL R Accession P16471 Amino Acid Sequence Gln25 Asp234, with C terminal 8*His QLPPGKPEIFKCRSPNKETFTCWWRPGTDGGLPTNYSLTYHREGETLMHECPDYITGGPNSCHFGKQYTSMWRTYIMMVNATNQMGSSFSDELYVDVTYIVQPDPPLELAVEVKQPEDRKPYLWIKWSPPTLIDLKTGWFTLLYEIRLKPEKAAEWEIHFAGQQTEFKILSLHPGQKYLVQVRCKPDHGYWSAWSPATFIQIPSDFTMNDGGGSHHHHHHHH Expression System HEK293 Molecular Weight 32 36kDa Purity >95% by SDS PAGE Endotoxin <0.
Product Specification
| Species | Human |
| Synonyms | Prolactin R, PRLR, PRL-R |
| Accession | P16471 |
| Amino Acid Sequence | Gln25-Asp234, with C-terminal 8*His QLPPGKPEIFKCRSPNKETFTCWWRPGTDGGLPTNYSLTYHREGETLMHECPDYITGGPNSCHFGKQYTSMWRTYIMMVNATNQMGSSFSDELYVDVTYIVQPDPPLELAVEVKQPEDRKPYLWIKWSPPTLIDLKTGWFTLLYEIRLKPEKAAEWEIHFAGQQTEFKILSLHPGQKYLVQVRCKPDHGYWSAWSPATFIQIPSDFTMNDGGGSHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | 32-36kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1、Bole-Feysot C. et al. (1998) Prolactin (PRL) and its receptor: actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice. Endocr Rev. 19(3): 225-268. |
Background
Prolactin receptor (PRLR) is a single-pass transmembrane receptor belonging to the type I cytokine receptor superfamily, and contains two fibronectin type-III domains. Knockout prolactin receptor gene (PRL-R) mice are animal models for prolactinomas and PRL acts via autocrine/paracrine inhibiting lactotroph proliferation. Recently, variants of the PRL-R were identified in prolactinoma patients and their frequency was higher compared to individuals from the genomic database. As a transmembrane receptor, the prolactin receptor (PRL-R) interacts with prolactin. The PRL-R also binds and is activated by growth hormone (GH) and human placental lactogen (hPL). Moreover, The PRLR has been found to be essential for lobuloalveolar maturation of the mammary glands during pregnancy, as evidenced by the fact that PRLR knockout mice show severely impaired development of lobuloalveolar structures.
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4.9 ★★★★★
Based on 9 reviews
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Product Reviews
★★★★★ 5
Great fetch toy
Color: Multicolor B, Size: 2.5"(Medium)-6 Pack
My German Shepherd LOVES these. The size, squeak, & quality is the Perfect fetch ball. I use a blue ball throwing launcher and they work Great together. Will be buying more of these
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Reviewed in the United States on May 31, 2026
★★★★★ 5
If you have dogs that like to play fetch, these are a must have!
Color: Orange - Pink, Size: 2.0"(Small)-4 Pack
My pups love these sp much, they won't play with any balls other than these. Not sure if it's the small size, or the fact that they squeek, but they def were a hit.
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Reviewed in the United States on May 12, 2026
★★★★★ 5
Fun balls for a small doggie
Our little Cockapoo loves these balls. When she can’t entice us to play, she has figured out how to bounce and chase a ball by herself - very cute!
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Reviewed in the United States on April 7, 2026
★★★★★ 5
Great for my aggressive chewers
Size: 1 Count (Pack of 1), Size: 1 Count (Pack of 1)
Wears my Labs out. Fred the yellow lab chooses this pig ear over all his nyla and natural chews out of the toy box all the time. This is the 4th one in his 6 years. They have lasted long and when new are large enough I don’t have to worry about choking. As they get down in size I throw them just as a precaution. The only con I can think of is Fred loves to slam it down on the pergola floor which makes for a very loud clacky sound and it scares the $%^ out of me. He of course thinks it’s funny so he picks it up and continues to do it. As long as he and his brother Willie can chew I will always have these in their toy box.
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Reviewed in the United States on March 14, 2024
★★★★★ 5
Good for strong chewers
Size: 1 Count (Pack of 1)
Great chew for for my GSDs! They last quite a while too.
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Reviewed in the United States on July 4, 2025