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Description
CHMP6/VPS20 Recombinant Rabbit mAb (S-1702-78)Product Specification Host Rabbit Antigen CHMP6 VPS20 Synonyms Charged multivesicular body protein 6; Chromatin modifying protein 6; Vacuolar protein sorting associated protein 20 (Vps20; hVps20) Immunogen Synthetic Peptide Location Endosome Accession Q96FZ7 Clone Number S 1702 78 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Ms, Rt Positive Sample mouse testis, mouse lung, rat lung Predicted Reactivity Gor Purification
Product Specification
| Host | Rabbit |
| Antigen | CHMP6/VPS20 |
| Synonyms | Charged multivesicular body protein 6; Chromatin-modifying protein 6; Vacuolar protein sorting-associated protein 20 (Vps20; hVps20) |
| Immunogen | Synthetic Peptide |
| Location | Endosome |
| Accession | Q96FZ7 |
| Clone Number | S-1702-78 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Ms, Rt |
| Positive Sample | mouse testis, mouse lung, rat lung |
| Predicted Reactivity | Gor |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Ms, Rt |
| IHC-P | 1:250 | Ms, Rt |
Background
CHMP6, also known as VPS20, is a protein encoded by the human gene CHMP6 and belongs to the charged multivesicular body protein family. It is a core component of the ESCRT-III (endosomal sorting complex required for transport III) complex, which is essential for the formation of multivesicular bodies (MVBs) and the sorting of endosomal cargo proteins into these MVBs. MVBs are involved in the degradation of membrane proteins, such as growth factor receptors, lysosomal enzymes, and lipids, by transporting them to lysosomes. CHMP6 is also known to interact with other components of the ESCRT machinery, such as CHMP4 and members of the ESCRT-II complex, to regulate cargo sorting and membrane remodeling processes. The protein is highly conserved across species and contains specific domains like coiled-coil structures and an N-myristoylation site, which are crucial for its function.
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