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Description
CD14 Recombinant Rabbit mAb (S-3533)Product Specification Host Rabbit Antigen CD14 Synonyms Monocyte differentiation antigen CD14; My23 antigen; Myeloid cell specific leucine rich glycoprotein Location Secreted, Cell membrane Accession P08571 Clone Number S 3533 Antibody Type Recombinant mAb Isotype IgG Application WB, ICC Reactivity Ms Positive Sample RAW264. 7, J774A. 1 Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer
Product Specification
| Host | Rabbit |
| Antigen | CD14 |
| Synonyms | Monocyte differentiation antigen CD14; My23 antigen; Myeloid cell-specific leucine-rich glycoprotein |
| Location | Secreted, Cell membrane |
| Accession | P08571 |
| Clone Number | S-3533 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, ICC |
| Reactivity | Ms |
| Positive Sample | RAW264.7, J774A.1 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:10000 | Ms |
| ICC | 1:500 | Ms |
Background
CD14 is a glycosylphosphatidylinositol (GPI)-anchored membrane glycoprotein primarily expressed on monocytes, macrophages, and some granulocytes. It functions as a pattern recognition receptor (PRR) and plays a crucial role in the innate immune response by recognizing bacterial lipopolysaccharides (LPS), pathogen-associated molecular patterns (PAMPs), and damage-associated molecular patterns (DAMPs). CD14 exists in two forms: membrane-bound CD14 (mCD14) and soluble CD14 (sCD14), which can be secreted by activated cells. It acts as a co-receptor for Toll-like receptor 4 (TLR4) and enhances the immune response to LPS by facilitating its delivery to the TLR4-MD2 complex. Additionally, CD14 is involved in TLR4-independent signaling pathways and contributes to tissue homeostasis by promoting the clearance of apoptotic cells.
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Exchange/Return Notes
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